Phencyclidine and the dynamics of mouse brain histamine

Y. Itoh, R. Oishi, Masahiro Nishibori, K. Saeki

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effects of phencyclidine (PCP) on the dynamics of brain histamine (HA) were examined in the mouse brain. PCP (2-10 mg/kg i.p.) dose-dependently elevated the level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, without altering the HA level. PCP also enhanced the accumulation of t-MH after administration of pargyline hydrochloride (80 mg/kg i.p.). PCP at 5 mg/kg facilitated the HA depletion produced by (S)-α-fluoromethylhistidine markedly (50 mg/kg i.v.), a specific inhibitor of histidine decarboxylase. Metoprine (10 mg/kg i.p.), an inhibitor of HA-N-methyltransferase, decreased the t-MH level and increased the HA level. In the metoprine-treated mice, PCP at 10 mg/kg had no significant effect on the t-MH level, whereas it significantly increased the HA level. The increase in t-MH level after administration of PCP (5 mg/kg) was observed in various brain regions except the pons-medulla oblongata. These results suggest that, in mice, PCP increases the brain HA turnover possibly by facilitating the release of HA.

Original languageEnglish
Pages (from-to)788-792
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume235
Issue number3
Publication statusPublished - 1985

Fingerprint

Phencyclidine
Histamine
Brain
Histamine N-Methyltransferase
Histidine Decarboxylase
Pargyline
Medulla Oblongata
Pons
Histamine Release
tele-methylhistamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Phencyclidine and the dynamics of mouse brain histamine. / Itoh, Y.; Oishi, R.; Nishibori, Masahiro; Saeki, K.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 235, No. 3, 1985, p. 788-792.

Research output: Contribution to journalArticle

@article{d742454cb48342b79f057d76bc2d363c,
title = "Phencyclidine and the dynamics of mouse brain histamine",
abstract = "The effects of phencyclidine (PCP) on the dynamics of brain histamine (HA) were examined in the mouse brain. PCP (2-10 mg/kg i.p.) dose-dependently elevated the level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, without altering the HA level. PCP also enhanced the accumulation of t-MH after administration of pargyline hydrochloride (80 mg/kg i.p.). PCP at 5 mg/kg facilitated the HA depletion produced by (S)-α-fluoromethylhistidine markedly (50 mg/kg i.v.), a specific inhibitor of histidine decarboxylase. Metoprine (10 mg/kg i.p.), an inhibitor of HA-N-methyltransferase, decreased the t-MH level and increased the HA level. In the metoprine-treated mice, PCP at 10 mg/kg had no significant effect on the t-MH level, whereas it significantly increased the HA level. The increase in t-MH level after administration of PCP (5 mg/kg) was observed in various brain regions except the pons-medulla oblongata. These results suggest that, in mice, PCP increases the brain HA turnover possibly by facilitating the release of HA.",
author = "Y. Itoh and R. Oishi and Masahiro Nishibori and K. Saeki",
year = "1985",
language = "English",
volume = "235",
pages = "788--792",
journal = "Journal of Pharmacology and Experimental Therapeutics",
issn = "0022-3565",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "3",

}

TY - JOUR

T1 - Phencyclidine and the dynamics of mouse brain histamine

AU - Itoh, Y.

AU - Oishi, R.

AU - Nishibori, Masahiro

AU - Saeki, K.

PY - 1985

Y1 - 1985

N2 - The effects of phencyclidine (PCP) on the dynamics of brain histamine (HA) were examined in the mouse brain. PCP (2-10 mg/kg i.p.) dose-dependently elevated the level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, without altering the HA level. PCP also enhanced the accumulation of t-MH after administration of pargyline hydrochloride (80 mg/kg i.p.). PCP at 5 mg/kg facilitated the HA depletion produced by (S)-α-fluoromethylhistidine markedly (50 mg/kg i.v.), a specific inhibitor of histidine decarboxylase. Metoprine (10 mg/kg i.p.), an inhibitor of HA-N-methyltransferase, decreased the t-MH level and increased the HA level. In the metoprine-treated mice, PCP at 10 mg/kg had no significant effect on the t-MH level, whereas it significantly increased the HA level. The increase in t-MH level after administration of PCP (5 mg/kg) was observed in various brain regions except the pons-medulla oblongata. These results suggest that, in mice, PCP increases the brain HA turnover possibly by facilitating the release of HA.

AB - The effects of phencyclidine (PCP) on the dynamics of brain histamine (HA) were examined in the mouse brain. PCP (2-10 mg/kg i.p.) dose-dependently elevated the level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, without altering the HA level. PCP also enhanced the accumulation of t-MH after administration of pargyline hydrochloride (80 mg/kg i.p.). PCP at 5 mg/kg facilitated the HA depletion produced by (S)-α-fluoromethylhistidine markedly (50 mg/kg i.v.), a specific inhibitor of histidine decarboxylase. Metoprine (10 mg/kg i.p.), an inhibitor of HA-N-methyltransferase, decreased the t-MH level and increased the HA level. In the metoprine-treated mice, PCP at 10 mg/kg had no significant effect on the t-MH level, whereas it significantly increased the HA level. The increase in t-MH level after administration of PCP (5 mg/kg) was observed in various brain regions except the pons-medulla oblongata. These results suggest that, in mice, PCP increases the brain HA turnover possibly by facilitating the release of HA.

UR - http://www.scopus.com/inward/record.url?scp=0022392826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022392826&partnerID=8YFLogxK

M3 - Article

VL - 235

SP - 788

EP - 792

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 3

ER -