Phase 2 study of 5'-DFUR for bladder and prostatic cancer

H. Ohmori, Y. Matsumura, J. Ochi, K. Kobashi, N. Akebi, T. Saika, K. Nanba, T. Tanahashi, T. Josen, Y. Nasu, M. Saegusa, Y. Ozaki, M. Hara, T. Asahi, N. Ike, T. Tsushima, N. Mitsuhata, T. Akagi, T. Kaeda

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3 Citations (Scopus)

Abstract

Phase 2 study of 5'-DFUR in bladder and prostatic cancer was conducted at 15 collaborative institutions including Okayama University. 5'-DFUR was orally administered to patients at a daily dose of 800-1200 mg for more than 4 weeks. Forty-one patients with bladder cancer and 12 patients with prostatic cancer were evaluated. The response rate for bladder cancer was 31.7% (CFR, 1 case: PR, 12 cases), against no response with prostatic cancer. Moreover, the concentration of 5-FU in bladder tumors was confirmed to be high. Adverse reactions such as diarrhea, anorexia, and nausea were observed. Thus, 5'-DFUR seems to be useful for the treatment of bladder cancer.

Original languageEnglish
Pages (from-to)2307-2314
Number of pages8
JournalJapanese Journal of Cancer and Chemotherapy
Volume18
Issue number13
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ohmori, H., Matsumura, Y., Ochi, J., Kobashi, K., Akebi, N., Saika, T., Nanba, K., Tanahashi, T., Josen, T., Nasu, Y., Saegusa, M., Ozaki, Y., Hara, M., Asahi, T., Ike, N., Tsushima, T., Mitsuhata, N., Akagi, T., & Kaeda, T. (1991). Phase 2 study of 5'-DFUR for bladder and prostatic cancer. Japanese Journal of Cancer and Chemotherapy, 18(13), 2307-2314.