Abstract
Phase 2 study of 5'-DFUR in bladder and prostatic cancer was conducted at 15 collaborative institutions including Okayama University. 5'-DFUR was orally administered to patients at a daily dose of 800-1200 mg for more than 4 weeks. Forty-one patients with bladder cancer and 12 patients with prostatic cancer were evaluated. The response rate for bladder cancer was 31.7% (CFR, 1 case: PR, 12 cases), against no response with prostatic cancer. Moreover, the concentration of 5-FU in bladder tumors was confirmed to be high. Adverse reactions such as diarrhea, anorexia, and nausea were observed. Thus, 5'-DFUR seems to be useful for the treatment of bladder cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 2307-2314 |
| Number of pages | 8 |
| Journal | Japanese Journal of Cancer and Chemotherapy |
| Volume | 18 |
| Issue number | 13 |
| Publication status | Published - Jan 1 1991 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Ohmori, H., Matsumura, Y., Ochi, J., Kobashi, K., Akebi, N., Saika, T., Nanba, K., Tanahashi, T., Josen, T., Nasu, Y., Saegusa, M., Ozaki, Y., Hara, M., Asahi, T., Ike, N., Tsushima, T., Mitsuhata, N., Akagi, T., & Kaeda, T. (1991). Phase 2 study of 5'-DFUR for bladder and prostatic cancer. Japanese Journal of Cancer and Chemotherapy, 18(13), 2307-2314.