Pharmacology of barbiturate tolerance/dependence: GABAA receptors and molecular aspects

Takehiko Ito, Toshihito Suzuki, Susan E. Wellman, Ing Kang Ho

Research output: Contribution to journalShort surveypeer-review

50 Citations (Scopus)


Barbiturates are central nervous system depressants that are used as sedatives, hypnotics, anesthetics and anticonvulsants. However, prolonged use of the drugs produces physical dependence, and the drugs have a high abuse liability. The gamma-aminobutyric acidA (GABAA) receptor is one of barbiturates' main sites of action, and therefore it is thought to play a pivotal role in the development of tolerance to and dependence on barbiturates. Recent advances in the study of the GABAA receptor/chloride channel complex allow us to examine possible mechanisms that underlie barbiturate tolerance/dependence in a new light. In this minireview, we mainly focus on molecular and cellular aspects of the action of barbiturates and the possible mechanisms that contribute to development of tolerance to and dependence on barbiturates.

Original languageEnglish
Pages (from-to)169-195
Number of pages27
JournalLife Sciences
Issue number3
Publication statusPublished - Jun 14 1996
Externally publishedYes


  • Barbiturate tolerance and dependence
  • Barbiturates
  • Drug abuse
  • GABA receptors
  • Protein kinases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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