Pharmacology of barbiturate tolerance/dependence: GABAA receptors and molecular aspects

Takehiko Ito, Toshihito Suzuki, Susan E. Wellman, Ing Kang Ho

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Barbiturates are central nervous system depressants that are used as sedatives, hypnotics, anesthetics and anticonvulsants. However, prolonged use of the drugs produces physical dependence, and the drugs have a high abuse liability. The gamma-aminobutyric acidA (GABAA) receptor is one of barbiturates' main sites of action, and therefore it is thought to play a pivotal role in the development of tolerance to and dependence on barbiturates. Recent advances in the study of the GABAA receptor/chloride channel complex allow us to examine possible mechanisms that underlie barbiturate tolerance/dependence in a new light. In this minireview, we mainly focus on molecular and cellular aspects of the action of barbiturates and the possible mechanisms that contribute to development of tolerance to and dependence on barbiturates.

Original languageEnglish
Pages (from-to)169-195
Number of pages27
JournalLife Sciences
Volume59
Issue number3
DOIs
Publication statusPublished - Jun 14 1996
Externally publishedYes

Fingerprint

Barbiturates
Pharmacology
Central Nervous System Depressants
Chloride Channels
Hypnotics and Sedatives
Pharmaceutical Preparations
Anticonvulsants
Substance-Related Disorders
Anesthetics
barbituric acid

Keywords

  • Barbiturate tolerance and dependence
  • Barbiturates
  • Drug abuse
  • GABA receptors
  • Protein kinases

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pharmacology of barbiturate tolerance/dependence : GABAA receptors and molecular aspects. / Ito, Takehiko; Suzuki, Toshihito; Wellman, Susan E.; Ho, Ing Kang.

In: Life Sciences, Vol. 59, No. 3, 14.06.1996, p. 169-195.

Research output: Contribution to journalArticle

Ito, Takehiko ; Suzuki, Toshihito ; Wellman, Susan E. ; Ho, Ing Kang. / Pharmacology of barbiturate tolerance/dependence : GABAA receptors and molecular aspects. In: Life Sciences. 1996 ; Vol. 59, No. 3. pp. 169-195.
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