Pharmacological activity of epoxide derivatives of Δ8-tetrahydrocannabinol (THC), 8α, 9α- and 8β, 9β-epoxyhexahydrocannabinol (EHHC), was compared with that of Δ8-THC in mice using catalepsy, hypothermia and prolongation of pentobarbital-induced sleep as index. ED50s for catalepsy of 8α, 9α,-EHHC, 8β, 9β-EHHC and Δ8-THC were 6.40, 0.87 and 3.30 mg/kg, i.v., respectively. The most effective cannabinoid inducing hypothermia was also 8β, 9β-EHHC followed by Δ8-THC. 8α, 9α-EHHC was least active. By treatments (5 mg/kg, i.v.) with 8α, 9α-EHHC, 8β, 9β-EHHC and Δ8-THC, pentobarbital-induced sleeping time was prolonged 1.7, 3.3 and 2.5 folds, respectively, as compared with that of 1% Tween 80-saline control. From these results, the pharmacological activity of the cannabinoids tested was ranked in the following order; 8β, 9β-EHHC > Δ8-THC>8α, 9α-EHHC.
|Number of pages||9|
|Journal||Research Communications in Substances of Abuse|
|Publication status||Published - Jan 1 1981|
ASJC Scopus subject areas
- Medicine (miscellaneous)