Pharmacological activities in mice of a nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9-trimethyl-(2-methyloxazolo)-[5,4-a]-6H-dibenzopyrane

S. Narimatsu, K. Shimozaki, T. Sugiyama, I. Yagi, K. Watanabe, I. Yamamoto, H. Yoshimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9- trimethyloxazolo-[5,4-a]-6H-dibenzopyrane (CBN-Ox), was synthesized from cannabinol (CBN) and its pharmacological activities in mice were compared with those of CBN using 3 indices of catalepsy, barbiturate synergism, and locomotor activity by intracerebroventricular injection. Pharmacological potencies of CBN-Ox were higher in cataleptogenic effect, but lower in barbiturate synergism and suppression of locomotor activity than those of CBN, suggesting that CBN-Ox may have some psychotropic activity in mice.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalResearch Communications in Substances of Abuse
Volume13
Issue number3
Publication statusPublished - 1992
Externally publishedYes

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Cannabinol
Cannabinoids
Nitrogen
Pharmacology
Locomotion
Catalepsy
Injections

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Pharmacological activities in mice of a nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9-trimethyl-(2-methyloxazolo)-[5,4-a]-6H-dibenzopyrane. / Narimatsu, S.; Shimozaki, K.; Sugiyama, T.; Yagi, I.; Watanabe, K.; Yamamoto, I.; Yoshimura, H.

In: Research Communications in Substances of Abuse, Vol. 13, No. 3, 1992, p. 247-255.

Research output: Contribution to journalArticle

Narimatsu, S, Shimozaki, K, Sugiyama, T, Yagi, I, Watanabe, K, Yamamoto, I & Yoshimura, H 1992, 'Pharmacological activities in mice of a nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9-trimethyl-(2-methyloxazolo)-[5,4-a]-6H-dibenzopyrane', Research Communications in Substances of Abuse, vol. 13, no. 3, pp. 247-255.
Narimatsu, S. ; Shimozaki, K. ; Sugiyama, T. ; Yagi, I. ; Watanabe, K. ; Yamamoto, I. ; Yoshimura, H. / Pharmacological activities in mice of a nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9-trimethyl-(2-methyloxazolo)-[5,4-a]-6H-dibenzopyrane. In: Research Communications in Substances of Abuse. 1992 ; Vol. 13, No. 3. pp. 247-255.
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AU - Yamamoto, I.

AU - Yoshimura, H.

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