Pharmacological activities in mice of a nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9-trimethyl-(2-methyloxazolo)-[5,4-a]-6H-dibenzopyrane

S. Narimatsu, K. Shimozaki, T. Sugiyama, I. Yagi, K. Watanabe, I. Yamamoto, H. Yoshimura

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6 Citations (Scopus)

Abstract

A nitrogen-containing cannabinoid, 3-pentyl-4-amino-6,6,9- trimethyloxazolo-[5,4-a]-6H-dibenzopyrane (CBN-Ox), was synthesized from cannabinol (CBN) and its pharmacological activities in mice were compared with those of CBN using 3 indices of catalepsy, barbiturate synergism, and locomotor activity by intracerebroventricular injection. Pharmacological potencies of CBN-Ox were higher in cataleptogenic effect, but lower in barbiturate synergism and suppression of locomotor activity than those of CBN, suggesting that CBN-Ox may have some psychotropic activity in mice.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalResearch Communications in Substances of Abuse
Volume13
Issue number3
Publication statusPublished - Jan 1 1992

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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