Pharmacokinetics of ritipenem acoxil

Noriaki Ono; Ryuji Fujita; Toyohiko Watanabe; Tadasu Takenaka; Kouichi Monden; Satoshi Uno; Koushi Sakuramoto; Toshihide Hayashi; Kazuhiro Hata; Yoshitsugu Nasu; Masaya Tsugawa; Hiromi Kumon; Hiroyuki Ohmori; Shin Irie; Tetsuzo Kaneshige

doi:10.11250/chemotherapy1995.43.Supplement3_286

Pharmacokinetics of ritipenem acoxil

Noriaki Ono, Ryuji Fujita, Toyohiko Watanabe, Tadasu Takenaka, Kouichi Monden, Satoshi Uno, Koushi Sakuramoto, Toshihide Hayashi, Kazuhiro Hata, Yoshitsugu Nasu, Masaya Tsugawa, Hiromi Kumon, Hiroyuki Ohmori, Shin Irie, Tetsuzo Kaneshige

Research output: Contribution to journal › Article › peer-review

Abstract

Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T_1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC_0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.

Original language	English
Pages (from-to)	286-291
Number of pages	6
Journal	Japanese Journal of Chemotherapy
Volume	43
DOIs	https://doi.org/10.11250/chemotherapy1995.43.Supplement3_286
Publication status	Published - Jan 1 1995

Keywords

cefoiam hexetil
ritipenem acoxil

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.11250/chemotherapy1995.43.Supplement3_286

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title = "Pharmacokinetics of ritipenem acoxil",

abstract = "Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.",

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author = "Noriaki Ono and Ryuji Fujita and Toyohiko Watanabe and Tadasu Takenaka and Kouichi Monden and Satoshi Uno and Koushi Sakuramoto and Toshihide Hayashi and Kazuhiro Hata and Yoshitsugu Nasu and Masaya Tsugawa and Hiromi Kumon and Hiroyuki Ohmori and Shin Irie and Tetsuzo Kaneshige",

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doi = "10.11250/chemotherapy1995.43.Supplement3_286",

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T1 - Pharmacokinetics of ritipenem acoxil

AU - Ono, Noriaki

AU - Fujita, Ryuji

AU - Watanabe, Toyohiko

AU - Takenaka, Tadasu

AU - Monden, Kouichi

AU - Uno, Satoshi

AU - Sakuramoto, Koushi

AU - Hayashi, Toshihide

AU - Hata, Kazuhiro

AU - Nasu, Yoshitsugu

AU - Tsugawa, Masaya

AU - Kumon, Hiromi

AU - Ohmori, Hiroyuki

AU - Irie, Shin

AU - Kaneshige, Tetsuzo

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.

AB - Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross-over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09μgg/ml and 2.85μg/ml, respectively. The T1/2 of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg·h/ml and 4.99 μg·h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.

KW - cefoiam hexetil

KW - ritipenem acoxil

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JO - Japanese Journal of Chemotherapy

JF - Japanese Journal of Chemotherapy

ER -

Pharmacokinetics of ritipenem acoxil

Abstract

Keywords

ASJC Scopus subject areas

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