Pharmacokinetics of ritipenem acoxil

N. Ono, R. Fujita, Toyohiko Watanabe, T. Takenaka, K. Monden, S. Uno, K. Sakuramoto, T. Hayashi, K. Hata, Y. Nasu, M. Tsugawa, H. Kumon, H. Ohmori, S. Irie, T. Kaneshige

Research output: Contribution to journalArticle

Abstract

Ritipenem acoxil (RIPM-AC) is a new oral penem antibiotic. We investigated the pharmacokinetics of RIPM-AC and cefotiam hexetil (CTM-HE) by the cross- over method. The pharmacokinetics of RIPM-AC and CTM-HE, each orally administrated at a dose of 200 mg, were compared in healthy male volunteers. The Cmax values of ritipenem (RIPM) and cefotiam (CTM) were 2.09 μg/ml and 2.85 μg/ml, respectively. The T( 1/2 ) of RIPM and CTM were 0.56 h and 0.71 h, and the AUC0-12 values were 2.10 μg · h/ml and 4.99 mg · h/ml. The mean urinary recovery rates of RIPM and CTM up to 12 h after a single oral administration were 11.3% and 38.9%.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalJapanese Journal of Chemotherapy
Volume43
Issue numberSUPPL. 3
Publication statusPublished - 1995

Fingerprint

Pharmacokinetics
Cefotiam
meropenem
Oral Administration
ritipenem
Healthy Volunteers
Anti-Bacterial Agents
cefotiam hexetil

Keywords

  • cefotiam hexetil
  • ritipenem acoxil

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ono, N., Fujita, R., Watanabe, T., Takenaka, T., Monden, K., Uno, S., ... Kaneshige, T. (1995). Pharmacokinetics of ritipenem acoxil. Japanese Journal of Chemotherapy, 43(SUPPL. 3), 286-291.

Pharmacokinetics of ritipenem acoxil. / Ono, N.; Fujita, R.; Watanabe, Toyohiko; Takenaka, T.; Monden, K.; Uno, S.; Sakuramoto, K.; Hayashi, T.; Hata, K.; Nasu, Y.; Tsugawa, M.; Kumon, H.; Ohmori, H.; Irie, S.; Kaneshige, T.

In: Japanese Journal of Chemotherapy, Vol. 43, No. SUPPL. 3, 1995, p. 286-291.

Research output: Contribution to journalArticle

Ono, N, Fujita, R, Watanabe, T, Takenaka, T, Monden, K, Uno, S, Sakuramoto, K, Hayashi, T, Hata, K, Nasu, Y, Tsugawa, M, Kumon, H, Ohmori, H, Irie, S & Kaneshige, T 1995, 'Pharmacokinetics of ritipenem acoxil', Japanese Journal of Chemotherapy, vol. 43, no. SUPPL. 3, pp. 286-291.
Ono N, Fujita R, Watanabe T, Takenaka T, Monden K, Uno S et al. Pharmacokinetics of ritipenem acoxil. Japanese Journal of Chemotherapy. 1995;43(SUPPL. 3):286-291.
Ono, N. ; Fujita, R. ; Watanabe, Toyohiko ; Takenaka, T. ; Monden, K. ; Uno, S. ; Sakuramoto, K. ; Hayashi, T. ; Hata, K. ; Nasu, Y. ; Tsugawa, M. ; Kumon, H. ; Ohmori, H. ; Irie, S. ; Kaneshige, T. / Pharmacokinetics of ritipenem acoxil. In: Japanese Journal of Chemotherapy. 1995 ; Vol. 43, No. SUPPL. 3. pp. 286-291.
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AU - Kaneshige, T.

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