Pharmacokinetics of glycyrrhizin in rats with D-galactosamine-induced hepatic disease

Zhao Wang, Mariko Okamoto, Yuji Kurosaki, Taiji Nakayama, Toshikiro Kimura

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The pharmacokinetic behavior of glycyrrihizin (GZ) was examined in D- galactosamine-intoxicated (GAL) rats. When GZ was administered intravenously, the apparent volume of distribution (Vd(ss)) and the total body clearance (CL(total)) were more significantly decreased in GAL rats than those in normal rats. When GZ was administered orally, the area under the plasma concentration-time curve (AUC), the mean residence time (MRT) and the time to reach the maximum plasma concentration (T(max)) for GZ were higher, but the maximum plasma concentration (Cp(max)) in GAL rats was lower than that in normal rats. The bioavailability of GZ, however, was not significantly changed. On the other hand, the AUC for glycyrrhetic acid (GA), a main metabolite of GZ, after oral administration of GZ was higher in GAL rats than in normal rats, although there was no significant difference in MRT or T(max), Cp(max) or the bioavailability for GA between GAL and normal rats. The reasons for these differences in GAL rats would be changes in the absorption rate (reduced gastric emptying rate) and reduction of the hepatic elimination rates (biliary excretion of GZ and hepatic metabolism of GA).

Original languageEnglish
Pages (from-to)901-904
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 1996

Keywords

  • glycyrrhetic acid
  • glycyrrhizin
  • hepatic disease
  • intestinal absorption
  • pharmacokinetics
  • rat

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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