Pharmacokinetics of Cefpiramide in Rats with Obstructive Jaundice

Toshikiro Kimura, Tadanao Yamao, Seiya Nakayama, Satoko Honge, Tomoko Kawakami, Yuji Kurosaki, Taiji Nakayama

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Changes in the mode of drug excretion in obstructive jaundice (OJ) were investigated in rats with experimentally induced OJ using a non-metabolized, highly-biliary-excreted antibiotic, cefpiramide (CPM). In OJ rats, biliary excretion of the drug was markedly diminished, while the urinary excretion was increased. The change in the mode of CPM excretion was examined in detail. It seems that the biliary excretion of CPM was decreased owing to the diminished biliary clearance in OJ rats. On the other hand, CPM binding to plasma proteins was decreased in the disease state. This change in the protein binding would be due to both the decreased albumin concentration and the accumulation of binding inhibitors in the plasma of diseased rats, and the decreased protein binding would be related not only to the increase in the volume of distribution but also to the increase in the renal clearance.

Original languageEnglish
Pages (from-to)839-848
Number of pages10
Journaljournal of pharmacobio-dynamics
Volume11
Issue number12
DOIs
Publication statusPublished - Feb 1 1988

Keywords

  • biliary excretion
  • cefpiramide
  • obstructive jaundice
  • pharmacokinetics
  • plasma protein binding
  • rat
  • urinary excretion

ASJC Scopus subject areas

  • Pharmacology

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