Pharmacokinetics of cefpiramide in rats acutely intoxicated with carbon tetrachloride

C. Li, S. Nakayama, Yuji Kurosaki, T. Nakayama, T. Kimura

Research output: Contribution to journalArticle

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Abstract

Pharmacokinetics of cefpiramide (CPM) were investigated in normal rats with hepatic intoxication induced by a single oral administration of carbon tetrachloride (CCl4). The elimination half-life of the antibiotic was prolonged in CCl4-intoxicated rats and the total body clearance in CCl4-intoxicated rats (153.9 ml/h/kg) was about 40% of the control value (390.3 ml/h/kg), while the volume of distribution for CPM was scarcely affected. The hepatic clearance of CPM was markedly diminished and the renal clearance of CPM was slightly, but not significantly, decreased in CCl4-intoxicated rats. It seems that the hepatic clearance of CPM was decreased owing to at least two factors; (1) decrease in CPM uptake by hepatocytes and (2) decrease in bile flow, while the renal clearance of CPM was slightly decreased owing to decrease in the renal tubular secretion. These results suggest that CCl4 intoxicates not only the liver but also the kidney to a small extent.

Original languageEnglish
Pages (from-to)186-194
Number of pages9
JournalJournal of Pharmacobio-Dynamics
Volume13
Issue number3
Publication statusPublished - 1990

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Carbon Tetrachloride
Pharmacokinetics
Kidney
Liver
cefpiramide
Bile
Oral Administration
Half-Life
Hepatocytes
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pharmacokinetics of cefpiramide in rats acutely intoxicated with carbon tetrachloride. / Li, C.; Nakayama, S.; Kurosaki, Yuji; Nakayama, T.; Kimura, T.

In: Journal of Pharmacobio-Dynamics, Vol. 13, No. 3, 1990, p. 186-194.

Research output: Contribution to journalArticle

Li, C. ; Nakayama, S. ; Kurosaki, Yuji ; Nakayama, T. ; Kimura, T. / Pharmacokinetics of cefpiramide in rats acutely intoxicated with carbon tetrachloride. In: Journal of Pharmacobio-Dynamics. 1990 ; Vol. 13, No. 3. pp. 186-194.
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