Pharmacokinetics of Agelastatin A in the central nervous system

Zhimin Li, Takuma Kamon, David A. Personett, Thomas Caulfield, John A. Copland, Takehiko Yoshimitsu, Han W. Tun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalMedChemComm
Volume3
Issue number2
DOIs
Publication statusPublished - Feb 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Li, Z., Kamon, T., Personett, D. A., Caulfield, T., Copland, J. A., Yoshimitsu, T., & Tun, H. W. (2012). Pharmacokinetics of Agelastatin A in the central nervous system. MedChemComm, 3(2), 233-237. https://doi.org/10.1039/c1md00240f