Pharmacokinetics of Agelastatin A in the central nervous system

Zhimin Li, Takuma Kamon, David A. Personett, Thomas Caulfield, John A. Copland, Takehiko Yoshimitsu, Han W. Tun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalMedChemComm
Volume3
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

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Pharmacokinetics
Neurology
Osteopontin
Central Nervous System
Brain Neoplasms
Tumors
Brain
agelastatin A

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Li, Z., Kamon, T., Personett, D. A., Caulfield, T., Copland, J. A., Yoshimitsu, T., & Tun, H. W. (2012). Pharmacokinetics of Agelastatin A in the central nervous system. MedChemComm, 3(2), 233-237. https://doi.org/10.1039/c1md00240f

Pharmacokinetics of Agelastatin A in the central nervous system. / Li, Zhimin; Kamon, Takuma; Personett, David A.; Caulfield, Thomas; Copland, John A.; Yoshimitsu, Takehiko; Tun, Han W.

In: MedChemComm, Vol. 3, No. 2, 02.2012, p. 233-237.

Research output: Contribution to journalArticle

Li, Z, Kamon, T, Personett, DA, Caulfield, T, Copland, JA, Yoshimitsu, T & Tun, HW 2012, 'Pharmacokinetics of Agelastatin A in the central nervous system', MedChemComm, vol. 3, no. 2, pp. 233-237. https://doi.org/10.1039/c1md00240f
Li Z, Kamon T, Personett DA, Caulfield T, Copland JA, Yoshimitsu T et al. Pharmacokinetics of Agelastatin A in the central nervous system. MedChemComm. 2012 Feb;3(2):233-237. https://doi.org/10.1039/c1md00240f
Li, Zhimin ; Kamon, Takuma ; Personett, David A. ; Caulfield, Thomas ; Copland, John A. ; Yoshimitsu, Takehiko ; Tun, Han W. / Pharmacokinetics of Agelastatin A in the central nervous system. In: MedChemComm. 2012 ; Vol. 3, No. 2. pp. 233-237.
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