Abstract
Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.
Original language | English |
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Pages (from-to) | 233-237 |
Number of pages | 5 |
Journal | MedChemComm |
Volume | 3 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2012 |
Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Pharmaceutical Science
Cite this
Pharmacokinetics of Agelastatin A in the central nervous system. / Li, Zhimin; Kamon, Takuma; Personett, David A.; Caulfield, Thomas; Copland, John A.; Yoshimitsu, Takehiko; Tun, Han W.
In: MedChemComm, Vol. 3, No. 2, 02.2012, p. 233-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of Agelastatin A in the central nervous system
AU - Li, Zhimin
AU - Kamon, Takuma
AU - Personett, David A.
AU - Caulfield, Thomas
AU - Copland, John A.
AU - Yoshimitsu, Takehiko
AU - Tun, Han W.
PY - 2012/2
Y1 - 2012/2
N2 - Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.
AB - Agelastatin A (AA) is an anti-neoplastic agent with anti-osteopontin (OPN) activity. Brain tumors often express OPN significantly. A comprehensive chemoinformatic analysis followed by in vivo pharmacokinetic evaluations in mice is performed. CNS penetration of AA is about 10%. AA should be further tested for activity against brain tumors.
UR - http://www.scopus.com/inward/record.url?scp=84863149318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863149318&partnerID=8YFLogxK
U2 - 10.1039/c1md00240f
DO - 10.1039/c1md00240f
M3 - Article
AN - SCOPUS:84863149318
VL - 3
SP - 233
EP - 237
JO - MedChemComm
JF - MedChemComm
SN - 2040-2503
IS - 2
ER -