Pharmacokinetics and safety of resveratrol derivatives in humans after oral administration of melinjo (Gnetum gnemon L.) seed extract powder

Hiroko Tani, Susumu Hikami, Sanae Iizuna, Maiko Yoshimatsu, Takashi Asama, Hidetaka Ota, Yuka Kimura, Tomoki Tatefuji, Ken Hashimoto, Kazutaka Higaki

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Fruits and seeds of melinjo (Gnetum gnemon L.) are resveratrol derivative-rich materials. Pharmacokinetics of resveratrol derivatives in healthy volunteers after oral administration of 1000 mg of melinjo seed extract (MSE) powder were assessed and compared with those after oral dosing of trans-resveratrol (tRV) powder containing 4.8 mg of tRV only, equivalent to the content in 1000 mg MSE powder. Plasma tRV concentrations with enzymatic hydrolysis were maintained over 24 h, with a tmax of 12 h and a mean residence time (MRT) of 14 h, 5 and 2 times higher than those for tRV powder intake, respectively. Gnetin C, a resveratrol dimer, with hydrolysis was maintained in plasma for >96 h with a 36 h MRT. With repeated doses once daily for 28 days, plasma tRV and gnetin C concentrations with hydrolysis were in good agreement with the theoretical curves. MSE powder was well tolerated up to the oral dosing of 5000 mg with no serious adverse events.

Original languageEnglish
Pages (from-to)1999-2007
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume62
Issue number8
DOIs
Publication statusPublished - Feb 26 2014

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Gnetum
Gnetum gnemon
Pharmacokinetics
seed extracts
resveratrol
Powders
oral administration
pharmacokinetics
Oral Administration
Seed
powders
Seeds
chemical derivatives
Derivatives
Safety
Hydrolysis
Plasmas
mouth
hydrolysis
Enzymatic hydrolysis

Keywords

  • human
  • melinjo seed extract
  • metabolites
  • plasma
  • resveratrol derivatives

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Pharmacokinetics and safety of resveratrol derivatives in humans after oral administration of melinjo (Gnetum gnemon L.) seed extract powder. / Tani, Hiroko; Hikami, Susumu; Iizuna, Sanae; Yoshimatsu, Maiko; Asama, Takashi; Ota, Hidetaka; Kimura, Yuka; Tatefuji, Tomoki; Hashimoto, Ken; Higaki, Kazutaka.

In: Journal of Agricultural and Food Chemistry, Vol. 62, No. 8, 26.02.2014, p. 1999-2007.

Research output: Contribution to journalArticle

Tani, Hiroko ; Hikami, Susumu ; Iizuna, Sanae ; Yoshimatsu, Maiko ; Asama, Takashi ; Ota, Hidetaka ; Kimura, Yuka ; Tatefuji, Tomoki ; Hashimoto, Ken ; Higaki, Kazutaka. / Pharmacokinetics and safety of resveratrol derivatives in humans after oral administration of melinjo (Gnetum gnemon L.) seed extract powder. In: Journal of Agricultural and Food Chemistry. 2014 ; Vol. 62, No. 8. pp. 1999-2007.
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