Pharmacokinetic analysis of flomoxef in children undergoing cardiopulmonary bypass and modified ultrafiltration

Zenichi Masuda, Yuji Kurosaki, Kozo Ishino, Keita Yamauchi, Shunji Sano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective. Cardiopulmonary bypass (CPB) induces changes in the pharmacokinetics of drugs. The purpose of this study was to model the pharmacokinetics of flomoxef, a cephalosporin antibiotic, in pediatric cardiac surgery. Methods. Each patient received a flomoxef dose of 30 mg/kg as a bolus after the induction of anesthesia and an additional dose (1 g for a child weighing

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalGeneral Thoracic and Cardiovascular Surgery
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Ultrafiltration
Cardiopulmonary Bypass
Pharmacokinetics
Cephalosporins
Thoracic Surgery
Anesthesia
Pediatrics
Pharmaceutical Preparations
flomoxef

Keywords

  • Cardiopulmonary bypass
  • Children
  • Flomoxef
  • Pharmacokinetics
  • Ultrafiltration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Pharmacokinetic analysis of flomoxef in children undergoing cardiopulmonary bypass and modified ultrafiltration. / Masuda, Zenichi; Kurosaki, Yuji; Ishino, Kozo; Yamauchi, Keita; Sano, Shunji.

In: General Thoracic and Cardiovascular Surgery, Vol. 56, No. 4, 04.2008, p. 163-169.

Research output: Contribution to journalArticle

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