Pharmacokinetic analysis of cefozopran in neonatal infections: Population pharmacokinetics using nonmem

Yuichi Sakurai, Tamotsu Hishikawa, Nobuyoshi Hiramatsu, Yasuhito Sagara, Masaaki Kuwahara, Masaru Nagasaki, Tomoko Hujimaki, Ryochi Fuji

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Abstract

This report describes the results on pharmacokinetics, efficacy and safety of cefozopran (CZOP) in neonatal patients. Enrolled patients were 136 in total whose informed consents to enter this study had been given by their parents. Among them, blood samples were collected from 42 neonates to analyze concentrations of CZOP by population pharmacokinetics (PPK) methods. Based on this analysis, the average pharmacokinetic parameters of CZOP and the variabilities of them in different morbid pharmacological backgrounds and in different subjects were evaluated. This PPK analysis showed that clearance (CL) and distribution volume (Vd) of CZOP could be estimated by the following equations; CL=0.0452XWT 1.75 (in the case of the postnatal age of over than 1 day) CL=0.623X0.0452WT 1.765 (in the case of the postnatal age of 1 day or less) Vd = 0.455XWT where WT indicates body weight in kg. The coefficients of variation among individual subjects on CL and Vd were found to he 20.7% and 20.0%, respectively. From this PPK analysis it was indicated that the elimination of CZOP is dependent on the postnatal age and is approximately 38% lower in the younger group than in the older group. Therefore, it could be concluded that, though the cases of evaluation were small in number, adjustment of dosing of CZOP is necessary, particularly in prolongation of intervals of administration, in cases of postnatal age of 1 day or less.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalJapanese Journal of Antibiotics
Volume52
Issue number1
Publication statusPublished - Jan 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Sakurai, Y., Hishikawa, T., Hiramatsu, N., Sagara, Y., Kuwahara, M., Nagasaki, M., Hujimaki, T., & Fuji, R. (1999). Pharmacokinetic analysis of cefozopran in neonatal infections: Population pharmacokinetics using nonmem. Japanese Journal of Antibiotics, 52(1), 16-23.