Pharmaceutical properties of a low-substituted hydroxypropyl cellulose (L-HPC) hydrogel as a novel external dressing

Atsushi Ogawa, Sachie Nakayama, Mami Uehara, Yasuhiro Mori, Mai Takahashi, Tetsuya Aiba, Yuji Kurosaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Controlling the moisture balance between exudates and their transpiration from the surface of wounded skin is important for healing. Low-substituted hydroxypropyl cellulose (L-HPC) hydrogel sheets (HGSs) possessing high water retention and water vapor transmission properties were prepared by neutralizing the highly viscous alkaline liquid of 7-10% L-HPC. Glycerol-impregnated L-HPC hydrogel sheets (L-HPC G-HGSs) were obtained by exchanging aqueous liquid in L-HPC HGSs. The physical characteristics required for wound dressings, i.e., mechanical strength, adhesive strength, and water retention properties, as well as the water vapor transmission (WVT) properties of L-HPC HGSs and L-HPC G-HGSs were evaluated. The mechanical strengths of L-HPC HGSs were enhanced with increases in the L-HPC content. The impregnation of glycerol in L-HPC HGSs yielded a significantly elasticated sheet. The adhesive strengths of L-HPC HGSs were significantly lower than those of commercial medical dressings. Water retention in L-HPC HGSs after being stored for 2 h at 37 °C was approximately 50%. The WVT rate of 7% L-HPC HGS was approximately 40 g/m2/h, which was markedly higher than that of silicone gel type medical dressings. In conclusion, L-HPC HGSs are promising dressings that maintain an adequate moisture balance by transpiring excessive wound exudates with less damage to the healing wound.

Original languageEnglish
Pages (from-to)546-552
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume477
Issue number1-2
DOIs
Publication statusPublished - Dec 30 2014

Keywords

  • Adhesive strength
  • Dressing
  • Hydrogel
  • Low-substituted hydroxypropyl cellulose (L-HPC)
  • Water retention
  • Water vapor transmission

ASJC Scopus subject areas

  • Pharmaceutical Science

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