Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum

Naonobu Tanaka, Takaaki Kubota, Haruaki Ishiyama, Atsushi Araki, Yoshiki Kashiwada, Yoshihisa Takaishi, Yuzuru Mikami, Jun'ichi Kobayashi

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1-3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A-C (1-3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.

Original languageEnglish
Pages (from-to)5619-5623
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number10
DOIs
Publication statusPublished - May 15 2008
Externally publishedYes

Keywords

  • Hypericum pseudopetiolatum var. kiusianum
  • Petiolins A-C
  • Phloroglucinol derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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