Perticipation of IL-18 in human cholestatic cirrhosis and acute rejection - Analysis in living donor liver transplantation

Takahito Yagi, Hiromi Iwagaki, Naoto Urushihara, Masahiro Oishi, Kenta Kobashi, Hideo Kohka, Hiroshi Sadamori, Masaru Inagaki, Norihisa Takakura, Toshihiro Higashi, Takao Tsuji, Tadashi Yoshino, Tadao Tanimoto, Masashi Kurimoto, Noriaki Tanaka

Research output: Contribution to journalArticlepeer-review

Abstract

We herein report the relationship between IL-18 and pathogenesis in patients who have cholestatic cirrhosis and acute rejection after living donor liver transplantation. Twenty-one healthy volunteers (control) and patients with obstructive jaundice (OBJ, n = 4), endostage PBC (PBC, n = 7), biliary atresia after failed Kasai's operation (BATx, n = 4) and biliary atresia after successful Kasai's operation (BANTx, n = 4) were examined. Altough serum IL-18 levels were closely correlated with total bilirubin levels in these patients, there were significant differences in sIL-18 levels between OBJ and PBC plus BA group. In all groups, hyper IL-18nemia was not accompanied by IFN-γ production. Since 6 patients (2 PBC and 4 BATx) underwent living donor liver transplantation. (LDLT) , post-transplant cytokine producing profiles including IFN-γ , IL-6, -10, -12, -18 were determined. After LDLT, IFN-γ levels in recipients'serum were increased and IFN-γ producing property of recipients was improved. Furthermore, sIL-18 levels were closely related with rejectional episodes after LDLT. IL-18 may be a key substance which regulates development of human cholestatic liver diseases and rejection after liver transplantation.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalJapanese Pharmacology and Therapeutics
Volume27
Issue numberSUPPL. 7
Publication statusPublished - Dec 1999

Keywords

  • Acute rejection
  • Cholestatic cirrhosis
  • IL-18

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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