Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess

Naomi Maeda, Hideharu Hagiya, Tsuyoshi Takiuchi, Shinsuke Kusakabe, Tetsuo Maeda, Keigo Kimura, Sayuri Iwai, Keisuke Kawasaki, Yumiko Hori, Eiichi Morii, Yuzuru Kanakura, Tadashi Kimura, Kazunori Tomono

Research output: Contribution to journalArticle

Abstract

Staphylococcus aureus as a pathogen in human gestational membranes, a rather rare phenomenon, has recently been the focus of several researches. S. aureus forms biofilms on these membranes and potentially causes chorioamnionitis in pregnant women. We report a case of persistent methicillin-resistant S. aureus (MRSA) bacteremia owing to placental infection, causing chorioamnionitis and preterm birth. A 29-year-old Japanese woman at the 27th gestational week was diagnosed with acute promyelocytic leukemia and underwent all-trans retinoic acid therapy. Soon after hospitalization, the patient presented with persistent MRSA bacteremia of unknown origin. Despite various antimicrobial therapies, she experienced 12 MRSA bacteremia episodes over 6 weeks. However, after child birth, MRSA bacteremia disappeared without any complications. A pathologic examination of her placenta revealed placenta abscess, resulting in a diagnosis of MRSA-associated chorioamnionitis. Molecular analysis proved that a single MRSA strain (SCCmec Type IVa), which tested negative for Panton–Valentine leukocidin and toxic shock syndrome toxin-1, caused the obstinate infection. We should be aware that persistent MRSA bacteremia in pregnant women can originate from placental abscess.

Original languageEnglish
Pages (from-to)975-979
Number of pages5
JournalJournal of Infection and Chemotherapy
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Bacteremia
Abscess
Chorioamnionitis
Placenta
Staphylococcus aureus
Pregnant Women
Leukocidins
Acute Promyelocytic Leukemia
Membranes
Premature Birth
Biofilms
Infection
Tretinoin
Hospitalization
Parturition
Therapeutics
Research

Keywords

  • Chorioamnionitis
  • Febrile neutropenia
  • Leukemia
  • Methicillin-resistant Staphylococcus aureus
  • Persistent bacteremia
  • Staphylococcus aureus bacteremia

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess. / Maeda, Naomi; Hagiya, Hideharu; Takiuchi, Tsuyoshi; Kusakabe, Shinsuke; Maeda, Tetsuo; Kimura, Keigo; Iwai, Sayuri; Kawasaki, Keisuke; Hori, Yumiko; Morii, Eiichi; Kanakura, Yuzuru; Kimura, Tadashi; Tomono, Kazunori.

In: Journal of Infection and Chemotherapy, Vol. 24, No. 12, 12.2018, p. 975-979.

Research output: Contribution to journalArticle

Maeda, N, Hagiya, H, Takiuchi, T, Kusakabe, S, Maeda, T, Kimura, K, Iwai, S, Kawasaki, K, Hori, Y, Morii, E, Kanakura, Y, Kimura, T & Tomono, K 2018, 'Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess', Journal of Infection and Chemotherapy, vol. 24, no. 12, pp. 975-979. https://doi.org/10.1016/j.jiac.2018.05.001
Maeda, Naomi ; Hagiya, Hideharu ; Takiuchi, Tsuyoshi ; Kusakabe, Shinsuke ; Maeda, Tetsuo ; Kimura, Keigo ; Iwai, Sayuri ; Kawasaki, Keisuke ; Hori, Yumiko ; Morii, Eiichi ; Kanakura, Yuzuru ; Kimura, Tadashi ; Tomono, Kazunori. / Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess. In: Journal of Infection and Chemotherapy. 2018 ; Vol. 24, No. 12. pp. 975-979.
@article{6e01941d93724852938fcfa38ef8acd5,
title = "Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess",
abstract = "Staphylococcus aureus as a pathogen in human gestational membranes, a rather rare phenomenon, has recently been the focus of several researches. S. aureus forms biofilms on these membranes and potentially causes chorioamnionitis in pregnant women. We report a case of persistent methicillin-resistant S. aureus (MRSA) bacteremia owing to placental infection, causing chorioamnionitis and preterm birth. A 29-year-old Japanese woman at the 27th gestational week was diagnosed with acute promyelocytic leukemia and underwent all-trans retinoic acid therapy. Soon after hospitalization, the patient presented with persistent MRSA bacteremia of unknown origin. Despite various antimicrobial therapies, she experienced 12 MRSA bacteremia episodes over 6 weeks. However, after child birth, MRSA bacteremia disappeared without any complications. A pathologic examination of her placenta revealed placenta abscess, resulting in a diagnosis of MRSA-associated chorioamnionitis. Molecular analysis proved that a single MRSA strain (SCCmec Type IVa), which tested negative for Panton–Valentine leukocidin and toxic shock syndrome toxin-1, caused the obstinate infection. We should be aware that persistent MRSA bacteremia in pregnant women can originate from placental abscess.",
keywords = "Chorioamnionitis, Febrile neutropenia, Leukemia, Methicillin-resistant Staphylococcus aureus, Persistent bacteremia, Staphylococcus aureus bacteremia",
author = "Naomi Maeda and Hideharu Hagiya and Tsuyoshi Takiuchi and Shinsuke Kusakabe and Tetsuo Maeda and Keigo Kimura and Sayuri Iwai and Keisuke Kawasaki and Yumiko Hori and Eiichi Morii and Yuzuru Kanakura and Tadashi Kimura and Kazunori Tomono",
year = "2018",
month = "12",
doi = "10.1016/j.jiac.2018.05.001",
language = "English",
volume = "24",
pages = "975--979",
journal = "Journal of Infection and Chemotherapy",
issn = "1341-321X",
publisher = "Elsevier BV",
number = "12",

}

TY - JOUR

T1 - Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess

AU - Maeda, Naomi

AU - Hagiya, Hideharu

AU - Takiuchi, Tsuyoshi

AU - Kusakabe, Shinsuke

AU - Maeda, Tetsuo

AU - Kimura, Keigo

AU - Iwai, Sayuri

AU - Kawasaki, Keisuke

AU - Hori, Yumiko

AU - Morii, Eiichi

AU - Kanakura, Yuzuru

AU - Kimura, Tadashi

AU - Tomono, Kazunori

PY - 2018/12

Y1 - 2018/12

N2 - Staphylococcus aureus as a pathogen in human gestational membranes, a rather rare phenomenon, has recently been the focus of several researches. S. aureus forms biofilms on these membranes and potentially causes chorioamnionitis in pregnant women. We report a case of persistent methicillin-resistant S. aureus (MRSA) bacteremia owing to placental infection, causing chorioamnionitis and preterm birth. A 29-year-old Japanese woman at the 27th gestational week was diagnosed with acute promyelocytic leukemia and underwent all-trans retinoic acid therapy. Soon after hospitalization, the patient presented with persistent MRSA bacteremia of unknown origin. Despite various antimicrobial therapies, she experienced 12 MRSA bacteremia episodes over 6 weeks. However, after child birth, MRSA bacteremia disappeared without any complications. A pathologic examination of her placenta revealed placenta abscess, resulting in a diagnosis of MRSA-associated chorioamnionitis. Molecular analysis proved that a single MRSA strain (SCCmec Type IVa), which tested negative for Panton–Valentine leukocidin and toxic shock syndrome toxin-1, caused the obstinate infection. We should be aware that persistent MRSA bacteremia in pregnant women can originate from placental abscess.

AB - Staphylococcus aureus as a pathogen in human gestational membranes, a rather rare phenomenon, has recently been the focus of several researches. S. aureus forms biofilms on these membranes and potentially causes chorioamnionitis in pregnant women. We report a case of persistent methicillin-resistant S. aureus (MRSA) bacteremia owing to placental infection, causing chorioamnionitis and preterm birth. A 29-year-old Japanese woman at the 27th gestational week was diagnosed with acute promyelocytic leukemia and underwent all-trans retinoic acid therapy. Soon after hospitalization, the patient presented with persistent MRSA bacteremia of unknown origin. Despite various antimicrobial therapies, she experienced 12 MRSA bacteremia episodes over 6 weeks. However, after child birth, MRSA bacteremia disappeared without any complications. A pathologic examination of her placenta revealed placenta abscess, resulting in a diagnosis of MRSA-associated chorioamnionitis. Molecular analysis proved that a single MRSA strain (SCCmec Type IVa), which tested negative for Panton–Valentine leukocidin and toxic shock syndrome toxin-1, caused the obstinate infection. We should be aware that persistent MRSA bacteremia in pregnant women can originate from placental abscess.

KW - Chorioamnionitis

KW - Febrile neutropenia

KW - Leukemia

KW - Methicillin-resistant Staphylococcus aureus

KW - Persistent bacteremia

KW - Staphylococcus aureus bacteremia

UR - http://www.scopus.com/inward/record.url?scp=85047275683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047275683&partnerID=8YFLogxK

U2 - 10.1016/j.jiac.2018.05.001

DO - 10.1016/j.jiac.2018.05.001

M3 - Article

C2 - 29804839

AN - SCOPUS:85047275683

VL - 24

SP - 975

EP - 979

JO - Journal of Infection and Chemotherapy

JF - Journal of Infection and Chemotherapy

SN - 1341-321X

IS - 12

ER -