Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient

Michiko Muraoka, Kana Washio, Kiichiro Kanamitu, Yui Kanazawa, Toshiaki Ishida, Takako Miyamura, Kosuke Chayama, Ritsuo Nishiuchi, Megumi Oda, Akira Shimada

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Abstract

Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)-negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical course, but CCA in pediatric CML patients are rarely reported. We herein report the case of an 8-year-old boy from the onset of CML. Although he had relapse after unrelated bone marrow transplantation when 9 years old, he has since been in complete molecular response on imatinib mesylate treatment. Surprisingly, various CCA have been observed in this patient, including several reciprocal chromosomal translocations in Ph-negative cells for >12 years. Although dysplasia in the bone marrow cells was identified, no overt transformation to myelodysplastic syndrome or acute myeloid leukemia has been observed. The cause of the CCA remains unknown in this patient, and careful observation is required.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalPediatrics International
Volume58
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • chromosome instability
  • chronic myelogenous leukemia
  • clonal chromosome abnormality
  • imatinib

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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  • Cite this

    Muraoka, M., Washio, K., Kanamitu, K., Kanazawa, Y., Ishida, T., Miyamura, T., Chayama, K., Nishiuchi, R., Oda, M., & Shimada, A. (2016). Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient. Pediatrics International, 58(1), 53-56. https://doi.org/10.1111/ped.12739