TY - JOUR
T1 - Persistent clonal chromosomal abnormalities in a chronic myeloid leukemia patient
AU - Muraoka, Michiko
AU - Washio, Kana
AU - Kanamitu, Kiichiro
AU - Kanazawa, Yui
AU - Ishida, Toshiaki
AU - Miyamura, Takako
AU - Chayama, Kosuke
AU - Nishiuchi, Ritsuo
AU - Oda, Megumi
AU - Shimada, Akira
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)-negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical course, but CCA in pediatric CML patients are rarely reported. We herein report the case of an 8-year-old boy from the onset of CML. Although he had relapse after unrelated bone marrow transplantation when 9 years old, he has since been in complete molecular response on imatinib mesylate treatment. Surprisingly, various CCA have been observed in this patient, including several reciprocal chromosomal translocations in Ph-negative cells for >12 years. Although dysplasia in the bone marrow cells was identified, no overt transformation to myelodysplastic syndrome or acute myeloid leukemia has been observed. The cause of the CCA remains unknown in this patient, and careful observation is required.
AB - Clonal cytogenetic abnormalities (CCA) in Philadelphia chromosome (Ph)-negative cells have been reported in a small population of adult chronic myelogenous leukemia (CML) patients during the clinical course, but CCA in pediatric CML patients are rarely reported. We herein report the case of an 8-year-old boy from the onset of CML. Although he had relapse after unrelated bone marrow transplantation when 9 years old, he has since been in complete molecular response on imatinib mesylate treatment. Surprisingly, various CCA have been observed in this patient, including several reciprocal chromosomal translocations in Ph-negative cells for >12 years. Although dysplasia in the bone marrow cells was identified, no overt transformation to myelodysplastic syndrome or acute myeloid leukemia has been observed. The cause of the CCA remains unknown in this patient, and careful observation is required.
KW - chromosome instability
KW - chronic myelogenous leukemia
KW - clonal chromosome abnormality
KW - imatinib
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U2 - 10.1111/ped.12739
DO - 10.1111/ped.12739
M3 - Article
C2 - 26542480
AN - SCOPUS:84956786318
VL - 58
SP - 53
EP - 56
JO - Pediatrics International
JF - Pediatrics International
SN - 1328-8067
IS - 1
ER -