Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: Laboratory photolysis, biodegradation, and sorption experiments

Hiroshi Yamamoto, Yudai Nakamura, Shigemi Moriguchi, Yuki Nakamura, Yuta Honda, Ikumi Tamura, Yoshiko Hirata, Akihide Hayashi, Jun Sekizawa

Research output: Contribution to journalArticle

296 Citations (Scopus)

Abstract

We selected eight pharmaceuticals with relatively high potential ecological risk and high consumption-namely, acetaminophen, atenolol, carbamazepine, ibuprofen, ifenprodil, indomethacin, mefenamic acid, and propranolol-and conducted laboratory experiments to examine the persistence and partitioning of these compounds in the aquatic environment. In the results of batch sunlight photolysis experiments, three out of eight pharmaceuticals-propranolol, indomethacin, and ifenprodil-were relatively easily photodegraded (i.e., half-life <24 h), whereas the other five pharmaceuticals were relatively stable against sunlight. The results of batch biodegradation experiments using river water suggested relatively slow biodegradation (i.e., half-life > 24 h) for all eight pharmaceuticals, but the rate constant was dependent on sampling site and time. Batch sorption experiments were also conducted to determine the sorption coefficients to river sediments and a model soil sample. The determined coefficients (Kd values) were much higher for three amines (atenolol, ifenprodil, and propranolol) than for neutral compounds or carboxylic acids; the Kd values of the amines were comparable to those of a four-ring polycyclic aromatic hydrocarbon (PAH) pyrene. The coefficients were also higher for sediment/soil with higher organic content, and the organic carbon-based sorption coefficient (log Koc) showed a poor linear correlation with the octanol-water distribution coefficient (log Dow) at neutral pH. These results suggest other sorption mechanisms-such as electrochemical affinity, in addition to hydrophobic interaction-play an important role in sorption to sediment/soil at neutral pH.

Original languageEnglish
Pages (from-to)351-362
Number of pages12
JournalWater Research
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

Fingerprint

Photolysis
photolysis
Biodegradation
Drug products
aquatic environment
Sorption
biodegradation
drug
partitioning
persistence
sorption
Sediments
Soils
experiment
Experiments
Amines
soil
Pyrene
carboxylic acid
Polycyclic aromatic hydrocarbons

Keywords

  • Biodegradation
  • Pharmaceuticals
  • Photolysis
  • Sediment
  • Sorption

ASJC Scopus subject areas

  • Water Science and Technology
  • Waste Management and Disposal
  • Pollution
  • Ecological Modelling

Cite this

Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment : Laboratory photolysis, biodegradation, and sorption experiments. / Yamamoto, Hiroshi; Nakamura, Yudai; Moriguchi, Shigemi; Nakamura, Yuki; Honda, Yuta; Tamura, Ikumi; Hirata, Yoshiko; Hayashi, Akihide; Sekizawa, Jun.

In: Water Research, Vol. 43, No. 2, 02.2009, p. 351-362.

Research output: Contribution to journalArticle

Yamamoto, Hiroshi ; Nakamura, Yudai ; Moriguchi, Shigemi ; Nakamura, Yuki ; Honda, Yuta ; Tamura, Ikumi ; Hirata, Yoshiko ; Hayashi, Akihide ; Sekizawa, Jun. / Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment : Laboratory photolysis, biodegradation, and sorption experiments. In: Water Research. 2009 ; Vol. 43, No. 2. pp. 351-362.
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AU - Nakamura, Yuki

AU - Honda, Yuta

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AB - We selected eight pharmaceuticals with relatively high potential ecological risk and high consumption-namely, acetaminophen, atenolol, carbamazepine, ibuprofen, ifenprodil, indomethacin, mefenamic acid, and propranolol-and conducted laboratory experiments to examine the persistence and partitioning of these compounds in the aquatic environment. In the results of batch sunlight photolysis experiments, three out of eight pharmaceuticals-propranolol, indomethacin, and ifenprodil-were relatively easily photodegraded (i.e., half-life <24 h), whereas the other five pharmaceuticals were relatively stable against sunlight. The results of batch biodegradation experiments using river water suggested relatively slow biodegradation (i.e., half-life > 24 h) for all eight pharmaceuticals, but the rate constant was dependent on sampling site and time. Batch sorption experiments were also conducted to determine the sorption coefficients to river sediments and a model soil sample. The determined coefficients (Kd values) were much higher for three amines (atenolol, ifenprodil, and propranolol) than for neutral compounds or carboxylic acids; the Kd values of the amines were comparable to those of a four-ring polycyclic aromatic hydrocarbon (PAH) pyrene. The coefficients were also higher for sediment/soil with higher organic content, and the organic carbon-based sorption coefficient (log Koc) showed a poor linear correlation with the octanol-water distribution coefficient (log Dow) at neutral pH. These results suggest other sorption mechanisms-such as electrochemical affinity, in addition to hydrophobic interaction-play an important role in sorption to sediment/soil at neutral pH.

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