In an attempt to develop a practically useful mimesis of peroxidase, the peroxidase-like catalytic activity of anion exchange resins (Amberlite IRA 900) modified with manganese, cobalt, iron, copper and zinc complexes of some porphyrins was examined in terms of the accelerating effect on dye formation in the following reaction. The evaluation of the activity was carried out by comparison of the effect obtained by using the resins with that obtained by using peroxidase. peroxidase 4-aminoantipyrine+ N, N,-diethylaniline + 2H202 →Peroxidase quinoid dye + 4H20 Amberlite IRA 900 modified with manganese-tetrakis(sulfophenyl)porphine was found to be the best among the resins tested.
- functionalization ion-exchange resin
- peroxidase mimesis
- peroxidase-like activity
- quinoid dye formation
- resin modified metalloporphyrin
ASJC Scopus subject areas
- Drug Discovery