Peritoneal dissemination of hepatocellular carcinoma treated with a combination therapy of interferon-alpha-2b and oral tegafur/uracil

Yasuhiro Miyake, Yoshiaki Iwasaki, Hidenori Shiraha, Kohsaku Sakaguchi, Yasushi Shiratori

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We encountered a case of peritoneal dissemination of hepatocellular carcinoma, successfully treated with a combination therapy of interferon-alpha-2b and oral tegafur/uracil. A 67-year-old Japanese man who underwent a hepatectomy developed peritoneal dissemination. A combination therapy of subcutaneous interferon-alpha-2b and intravenous 5-fluorouracil was started. Four weeks later, he felt severe general fatigue and nausea, and intravenous 5-fluorouracil was replaced with oral tegafur/uracil. At 3 months after the initiation of chemotherapy, enhanced computed tomography showed markedly reduced peritoneal dissemination. A combination therapy of interferon-alpha-2b and oral tegafur/uracil is facile and may be effective for extrahepatic metastasis of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalInternal Medicine
Volume46
Issue number9
DOIs
Publication statusPublished - May 1 2007

Fingerprint

interferon alfa-2b
Tegafur
Uracil
Hepatocellular Carcinoma
Fluorouracil
Hepatectomy
Nausea
Fatigue
Therapeutics
Tomography
Neoplasm Metastasis
Drug Therapy

Keywords

  • 5-fluorouracil
  • Extrahepatic metastasis
  • Systemic chemotherapy

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Peritoneal dissemination of hepatocellular carcinoma treated with a combination therapy of interferon-alpha-2b and oral tegafur/uracil. / Miyake, Yasuhiro; Iwasaki, Yoshiaki; Shiraha, Hidenori; Sakaguchi, Kohsaku; Shiratori, Yasushi.

In: Internal Medicine, Vol. 46, No. 9, 01.05.2007, p. 565-569.

Research output: Contribution to journalArticle

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