Peripheral T/natural killer-cell lymphoma involving the female genital tract: a clinicopathologic study of 5 cases

Shigeo Nakamura, Miyuki Kato, Koichi Ichimura, Yasushi Yatabe, Yoshitoyo Kagami, Ritsuro Suzuki, Hirohumi Taji, Eisei Kondo, Shoji Asakura, Masaru Kojima, Sakae Murakami, Kumi Yamao, Toyonori Tsuzuki, Koichi Adachi, Atsuo Miwa, Takashi Yoshida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Malignant lymphoma of the female genital tract (FGT) is rare. In this study, 5 peripheral T/natural killer (NK)-cell lymphomas (PTCLs) involving the FGT are reported. They include 2 from the uterus and 1 each from ovary, uterus and ovary, and vagina, and were detected between 1996 and 2000. One of the 2 ovarian tumors was bilateral. In all cases, the FGT was the initial site of clinical presentation of disease. Age at presentation ranged from 21 to 52 years (median, 36 years). One case was stage I disease, 2 were stage II, and 2 were stage IV. All 5 tumors were positive for CD3epsilon, and 3 harbored the Epstein-Barr virus, although the detailed immunophenotypic profiles varied. Three were diagnosed as nasal type T/NK-cell lymphoma, 1 as anaplastic large-cell lymphoma (anaplastic lymphoma kinase [ALK]-positive), and 1 as unspecified PTCL of cytotoxic phenotype, according to the forthcoming World Health Organization classification. Four of 5 patients received laparotomy and chemotherapy. Four patients (in stages II and IV) died of disease within 16 months of the initial diagnosis, whereas only 1 patient (in stage I) is alive without disease at 39 months of follow-up. Our experience in this series provided clinically relevant information on diagnosis, treatment, and outcome for extremely rare tumors of the FGT.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalInternational journal of hematology
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 2001

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Peripheral T/natural killer-cell lymphoma involving the female genital tract: a clinicopathologic study of 5 cases'. Together they form a unique fingerprint.

  • Cite this

    Nakamura, S., Kato, M., Ichimura, K., Yatabe, Y., Kagami, Y., Suzuki, R., Taji, H., Kondo, E., Asakura, S., Kojima, M., Murakami, S., Yamao, K., Tsuzuki, T., Adachi, K., Miwa, A., & Yoshida, T. (2001). Peripheral T/natural killer-cell lymphoma involving the female genital tract: a clinicopathologic study of 5 cases. International journal of hematology, 73(1), 108-114. https://doi.org/10.1007/BF02981911