Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis

Junichi Kitagawa, Naoe Goto, Yuhei Shibata, Nobuhiko Nakamura, Hiroshi Nakamura, Nobuhiro Kanemura, Takeshi Hara, Katsuyoshi Takata, Yasuharu Sato, Tadashi Yoshino, Hisashi Tsurumi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Concurrent seminoma and malignant lymphoma of the testis is rare. We present a case of concurrent seminoma and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) in a 54-year-old man who complained of painless left testicular enlargement. Radical left orchiectomy was performed. Macroscopically, the tumor (4.0 × 3.0 cm) was creamy, soft, and homogeneous, and microscopic evaluation revealed an alveolar structure of large cells that formed sheets, as well as colonization by other abnormal cells in a 1.0 × 1.0 cm area. The portion of the tumor comprising large abnormal cells was diagnosed as a seminoma, which was positive for c-kit by immunohistochemistry; the other portion was diagnosed as CD3/CD8, TIA, and granzyme B-positive PTCL-NOS. These two portions were clearly differentiated from one another. The patient received CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) therapy and achieved complete response for 50 months. To our knowledge, this is the first reported case of synchronous advanced seminoma and PTCL.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalJournal of clinical and experimental hematopathology : JCEH
Volume55
Issue number3
DOIs
Publication statusPublished - 2015
Externally publishedYes

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Peripheral T-Cell Lymphoma
Seminoma
Testis
Granzymes
Orchiectomy
Vincristine
Prednisolone
Doxorubicin
Cyclophosphamide
Lymphoma
Neoplasms
Immunohistochemistry

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kitagawa, J., Goto, N., Shibata, Y., Nakamura, N., Nakamura, H., Kanemura, N., ... Tsurumi, H. (2015). Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis. Journal of clinical and experimental hematopathology : JCEH, 55(3), 169-174. https://doi.org/10.3960/jslrt.55.169

Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis. / Kitagawa, Junichi; Goto, Naoe; Shibata, Yuhei; Nakamura, Nobuhiko; Nakamura, Hiroshi; Kanemura, Nobuhiro; Hara, Takeshi; Takata, Katsuyoshi; Sato, Yasuharu; Yoshino, Tadashi; Tsurumi, Hisashi.

In: Journal of clinical and experimental hematopathology : JCEH, Vol. 55, No. 3, 2015, p. 169-174.

Research output: Contribution to journalArticle

Kitagawa, J, Goto, N, Shibata, Y, Nakamura, N, Nakamura, H, Kanemura, N, Hara, T, Takata, K, Sato, Y, Yoshino, T & Tsurumi, H 2015, 'Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis', Journal of clinical and experimental hematopathology : JCEH, vol. 55, no. 3, pp. 169-174. https://doi.org/10.3960/jslrt.55.169
Kitagawa, Junichi ; Goto, Naoe ; Shibata, Yuhei ; Nakamura, Nobuhiko ; Nakamura, Hiroshi ; Kanemura, Nobuhiro ; Hara, Takeshi ; Takata, Katsuyoshi ; Sato, Yasuharu ; Yoshino, Tadashi ; Tsurumi, Hisashi. / Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis. In: Journal of clinical and experimental hematopathology : JCEH. 2015 ; Vol. 55, No. 3. pp. 169-174.
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