Peripheral neuroglial death induced by cisplatin administration in newborn rats

Tomosada Sugimoto, Akihiro Takeyama, Masako Fujita, Hiroyuki Ichikawa, Teruko Takano-Yamamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To determine the target of cytotoxicity of cisplatin (CDDP), we injected newborn rats with 2mg/kg CDDP and examined the trigeminal ganglion for possible cell death. A nick translation method for DNA fragmentation revealed CDDP-induced glial cell death. DNA fragmentation was detected in both Schwann cells and satellite cells. Satellite cell death was observed as early as 0.5 day after injection, most frequent at 1-3 days and subsided thereafter. The incidence of neuronal death was very low and comparable to that observed in vehicle control rats. CDDP has selective toxicity to peripheral glial cells, though the damage did not culminate in cell death in adults. The glial toxicity may contribute to clinical symptoms of CDDP neuropathy.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalNeuroReport
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 22 2001

Keywords

  • Cisplatin
  • Newborn rats
  • Satellite cells
  • Schwann cells
  • Toxicity
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)

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    Sugimoto, T., Takeyama, A., Fujita, M., Ichikawa, H., & Takano-Yamamoto, T. (2001). Peripheral neuroglial death induced by cisplatin administration in newborn rats. NeuroReport, 12(1), 137-140. https://doi.org/10.1097/00001756-200101220-00035