Peripheral circadian rhythms and their regulatory mechanism in insects and some other arthropods: A review

Kenji Tomioka, Outa Uryu, Yuichi Kamae, Yujiro Umezaki, Taishi Yoshii

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Many physiological functions of insects show a rhythmic change to adapt to daily environmental cycles. These rhythms are controlled by a multi-clock system. A principal clock located in the brain usually organizes the overall behavioral rhythms, so that it is called the "central clock". However, the rhythms observed in a variety of peripheral tissues are often driven by clocks that reside in those tissues. Such autonomous rhythms can be found in sensory organs, digestive and reproductive systems. Using Drosophila melanogaster as a model organism, researchers have revealed that the peripheral clocks are self-sustained oscillators with a molecular machinery slightly different from that of the central clock. However, individual clocks normally run in harmony with each other to keep a coordinated temporal structure within an animal. How can this be achieved? What is the molecular mechanism underlying the oscillation? Also how are the peripheral clocks entrained by light-dark cycles? There are still many questions remaining in this research field. In the last several years, molecular techniques have become available in non-model insects so that the molecular oscillatory mechanisms are comparatively investigated among different insects, which give us more hints to understand the essential regulatory mechanism of the multi-oscillatory system across insects and other arthropods. Here we review current knowledge on arthropod's peripheral clocks and discuss their physiological roles and molecular mechanisms.

Original languageEnglish
Pages (from-to)729-740
Number of pages12
JournalJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
Volume182
Issue number6
DOIs
Publication statusPublished - Aug 1 2012

Keywords

  • Circadian clock
  • Clock gene
  • Entrainment
  • Molecular oscillation
  • Peripheral clock

ASJC Scopus subject areas

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Animal Science and Zoology
  • Endocrinology

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