Peripheral arterial endothelial dysfunction of neurodegenerative diseases

Yusuke Fukui, Nozomi Hishikawa, Jingwei Shang, Kota Sato, Yumiko Nakano, Ryuta Morihara, Yasuyuki Ohta, Toru Yamashita, Koji Abe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study evaluates endothelial functions of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and spinocerebellar ataxia (SCA). The reactive hyperemia index (RHI) of peripheral arterial tonometry and serological data were compared between age- and gender-matched normal controls (n = 302) and five disease groups (ALS; n = 75, PD; n = 180, PSP; n = 30, MSA; n = 35, SCA; n = 53). Correlation analyses were performed in ALS with functional rating scale-revised (FRS-R), and in PD with the Hehn-Yahr scale (H-Y) and a heart to mediastinum ratio using 123I-MIBG scintigraphy (MIBG). The RHI of ALS and PD, but not of PSP, MSA or SCA, were significantly lower than normal controls (p <0.01). ALS showed a negative correlation of RHI with serum triglycerides (TG) and immunoreactive insulin (IRI) levels, but not with disease severity (FRS-R) or rates of disease progression (δ FRS-R). On the other hand, PD showed a negative correlation of RHI with a progressive disease severity (H-Y) and a positive correlation of RHI with early/delayed MIBG scintigraphy, but not with serological data. The present study demonstrated significant declines of peripheral arterial endothelial functions in ALS and PD. The RHI of ALS was more correlated with disease duration and serum parameters while the RHI of PD was more correlated with disease severity and MIBG, suggesting different mechanisms of endothelial dysfunction.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalJournal of the Neurological Sciences
Volume366
DOIs
Publication statusPublished - Jul 15 2016

Fingerprint

Hyperemia
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Parkinson Disease
3-Iodobenzylguanidine
Progressive Supranuclear Palsy
Multiple System Atrophy
Spinocerebellar Ataxias
Radionuclide Imaging
Manometry
Mediastinum
Serum
Disease Progression
Triglycerides
Insulin

Keywords

  • Amyotrophic lateral sclerosis
  • Endothelial function
  • Multiple system atrophy
  • Parkinson's disease
  • Progressive supranuclear palsy
  • Spinocerebellar ataxia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Peripheral arterial endothelial dysfunction of neurodegenerative diseases. / Fukui, Yusuke; Hishikawa, Nozomi; Shang, Jingwei; Sato, Kota; Nakano, Yumiko; Morihara, Ryuta; Ohta, Yasuyuki; Yamashita, Toru; Abe, Koji.

In: Journal of the Neurological Sciences, Vol. 366, 15.07.2016, p. 94-99.

Research output: Contribution to journalArticle

@article{577625791f8c4b93a2e32ad14cfb7168,
title = "Peripheral arterial endothelial dysfunction of neurodegenerative diseases",
abstract = "This study evaluates endothelial functions of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and spinocerebellar ataxia (SCA). The reactive hyperemia index (RHI) of peripheral arterial tonometry and serological data were compared between age- and gender-matched normal controls (n = 302) and five disease groups (ALS; n = 75, PD; n = 180, PSP; n = 30, MSA; n = 35, SCA; n = 53). Correlation analyses were performed in ALS with functional rating scale-revised (FRS-R), and in PD with the Hehn-Yahr scale (H-Y) and a heart to mediastinum ratio using 123I-MIBG scintigraphy (MIBG). The RHI of ALS and PD, but not of PSP, MSA or SCA, were significantly lower than normal controls (p <0.01). ALS showed a negative correlation of RHI with serum triglycerides (TG) and immunoreactive insulin (IRI) levels, but not with disease severity (FRS-R) or rates of disease progression (δ FRS-R). On the other hand, PD showed a negative correlation of RHI with a progressive disease severity (H-Y) and a positive correlation of RHI with early/delayed MIBG scintigraphy, but not with serological data. The present study demonstrated significant declines of peripheral arterial endothelial functions in ALS and PD. The RHI of ALS was more correlated with disease duration and serum parameters while the RHI of PD was more correlated with disease severity and MIBG, suggesting different mechanisms of endothelial dysfunction.",
keywords = "Amyotrophic lateral sclerosis, Endothelial function, Multiple system atrophy, Parkinson's disease, Progressive supranuclear palsy, Spinocerebellar ataxia",
author = "Yusuke Fukui and Nozomi Hishikawa and Jingwei Shang and Kota Sato and Yumiko Nakano and Ryuta Morihara and Yasuyuki Ohta and Toru Yamashita and Koji Abe",
year = "2016",
month = "7",
day = "15",
doi = "10.1016/j.jns.2016.04.042",
language = "English",
volume = "366",
pages = "94--99",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Peripheral arterial endothelial dysfunction of neurodegenerative diseases

AU - Fukui, Yusuke

AU - Hishikawa, Nozomi

AU - Shang, Jingwei

AU - Sato, Kota

AU - Nakano, Yumiko

AU - Morihara, Ryuta

AU - Ohta, Yasuyuki

AU - Yamashita, Toru

AU - Abe, Koji

PY - 2016/7/15

Y1 - 2016/7/15

N2 - This study evaluates endothelial functions of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and spinocerebellar ataxia (SCA). The reactive hyperemia index (RHI) of peripheral arterial tonometry and serological data were compared between age- and gender-matched normal controls (n = 302) and five disease groups (ALS; n = 75, PD; n = 180, PSP; n = 30, MSA; n = 35, SCA; n = 53). Correlation analyses were performed in ALS with functional rating scale-revised (FRS-R), and in PD with the Hehn-Yahr scale (H-Y) and a heart to mediastinum ratio using 123I-MIBG scintigraphy (MIBG). The RHI of ALS and PD, but not of PSP, MSA or SCA, were significantly lower than normal controls (p <0.01). ALS showed a negative correlation of RHI with serum triglycerides (TG) and immunoreactive insulin (IRI) levels, but not with disease severity (FRS-R) or rates of disease progression (δ FRS-R). On the other hand, PD showed a negative correlation of RHI with a progressive disease severity (H-Y) and a positive correlation of RHI with early/delayed MIBG scintigraphy, but not with serological data. The present study demonstrated significant declines of peripheral arterial endothelial functions in ALS and PD. The RHI of ALS was more correlated with disease duration and serum parameters while the RHI of PD was more correlated with disease severity and MIBG, suggesting different mechanisms of endothelial dysfunction.

AB - This study evaluates endothelial functions of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and spinocerebellar ataxia (SCA). The reactive hyperemia index (RHI) of peripheral arterial tonometry and serological data were compared between age- and gender-matched normal controls (n = 302) and five disease groups (ALS; n = 75, PD; n = 180, PSP; n = 30, MSA; n = 35, SCA; n = 53). Correlation analyses were performed in ALS with functional rating scale-revised (FRS-R), and in PD with the Hehn-Yahr scale (H-Y) and a heart to mediastinum ratio using 123I-MIBG scintigraphy (MIBG). The RHI of ALS and PD, but not of PSP, MSA or SCA, were significantly lower than normal controls (p <0.01). ALS showed a negative correlation of RHI with serum triglycerides (TG) and immunoreactive insulin (IRI) levels, but not with disease severity (FRS-R) or rates of disease progression (δ FRS-R). On the other hand, PD showed a negative correlation of RHI with a progressive disease severity (H-Y) and a positive correlation of RHI with early/delayed MIBG scintigraphy, but not with serological data. The present study demonstrated significant declines of peripheral arterial endothelial functions in ALS and PD. The RHI of ALS was more correlated with disease duration and serum parameters while the RHI of PD was more correlated with disease severity and MIBG, suggesting different mechanisms of endothelial dysfunction.

KW - Amyotrophic lateral sclerosis

KW - Endothelial function

KW - Multiple system atrophy

KW - Parkinson's disease

KW - Progressive supranuclear palsy

KW - Spinocerebellar ataxia

UR - http://www.scopus.com/inward/record.url?scp=84967104354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84967104354&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2016.04.042

DO - 10.1016/j.jns.2016.04.042

M3 - Article

C2 - 27288784

AN - SCOPUS:84967104354

VL - 366

SP - 94

EP - 99

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -