Periodontal infection and dyslipidemia in type 2 diabetics

Association with increased HMG-CoA reductase expression

F. Nishimura, A. Taniguchi, M. Yamaguchi-Morimoto, Yoshihiko Soga, Y. Iwamoto, Susumu Kokeguchi, A. Kuroe, M. Fukushima, Y. Nakai, Y. Seino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Recent studies have suggested that the periodontal disease, chronic sub-clinical inflammation, is associated with atherosclerosis, although "cause or effect" relationship is still unclear. The aim of this study was to assess the association between the degree of periodontal infection and lipid profiles in diabetic subjects. Additionally, the association of such sub-clinical inflammation with HMG-CoA reductase gene expression was evaluated. One hundred and thirty-one non-obese relatively well-controlled Japanese type 2 diabetic patients were enrolled for the study. Although no significant association was observed between serum triglycerides, HLD-cholesterol and antibody titer to Porphyromonas gingivalis (Pg), the most predominant periodontal pathogen in adults, LDL-cholesterol was significantly associated with antibody titer to Pg. Concomitantly, the same works out to be true for total cholesterol. To understand the possible mechanisms underlying this association, we evaluated 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase gene expression in cultured HepG2 cells stimulated by either bacterial lipopolysaccharide (LPS) or inflammatory cytokines. Although Pg and E. coli LPS had no effect on HMG-CoA reductase gene expression, both tumor necrosis factor-α and interleukin-6 (IL-6), especially IL-6 at low concentration, markedly up-regulated HMG-CoA reductase gene expression. It can be concluded that Pg infection is associated with increased LDL-cholesterol in diabetic subjects, which may be accompanied by increased cholesterol synthesis by inflammatory cytokines.

Original languageEnglish
Pages (from-to)530-535
Number of pages6
JournalHormone and Metabolic Research
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Hydroxymethylglutaryl CoA Reductases
Porphyromonas gingivalis
Dyslipidemias
Gene expression
Association reactions
Gene Expression
Cholesterol
Infection
LDL Cholesterol
Lipopolysaccharides
Interleukin-6
Cytokines
Inflammation
Antibodies
Hep G2 Cells
Periodontal Diseases
Pathogens
Escherichia coli
Cultured Cells
Atherosclerosis

Keywords

  • Atherosclerosis
  • Diabetes
  • Dyslipidemia
  • HMG-CoA reductase
  • Infection

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Periodontal infection and dyslipidemia in type 2 diabetics : Association with increased HMG-CoA reductase expression. / Nishimura, F.; Taniguchi, A.; Yamaguchi-Morimoto, M.; Soga, Yoshihiko; Iwamoto, Y.; Kokeguchi, Susumu; Kuroe, A.; Fukushima, M.; Nakai, Y.; Seino, Y.

In: Hormone and Metabolic Research, Vol. 38, No. 8, 08.2006, p. 530-535.

Research output: Contribution to journalArticle

Nishimura, F, Taniguchi, A, Yamaguchi-Morimoto, M, Soga, Y, Iwamoto, Y, Kokeguchi, S, Kuroe, A, Fukushima, M, Nakai, Y & Seino, Y 2006, 'Periodontal infection and dyslipidemia in type 2 diabetics: Association with increased HMG-CoA reductase expression', Hormone and Metabolic Research, vol. 38, no. 8, pp. 530-535. https://doi.org/10.1055/s-2006-949525
Nishimura, F. ; Taniguchi, A. ; Yamaguchi-Morimoto, M. ; Soga, Yoshihiko ; Iwamoto, Y. ; Kokeguchi, Susumu ; Kuroe, A. ; Fukushima, M. ; Nakai, Y. ; Seino, Y. / Periodontal infection and dyslipidemia in type 2 diabetics : Association with increased HMG-CoA reductase expression. In: Hormone and Metabolic Research. 2006 ; Vol. 38, No. 8. pp. 530-535.
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