Periodontal disease and diabetes mellitus

The role of tumor necrosis factor-α in a 2-way relationship

Fusanori Nishimura, Yoshihiro Iwamoto, Junji Mineshiba, Akemi Shimizu, Yoshihiko Soga, Yoji Murayama

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

It is generally accepted that obesity is associated with many other multiple-risk factor syndromes such as hypertension, hyperlipidemia, type 2 diabetes mellitus, and periodontal disease. The number of obese people is increasing rapidly in both western and eastern countries. Adipocytes in the adipose tissues of obese people produce large quantities of biologically active molecules such as leptin, an important molecule regulating energy expenditure and body weight. Therefore, adipocyte-derived active molecules, named adipocytokines, are candidate molecules accounting for the close association between obesity and other multiple-risk factor syndromes. The proinflammatory cytokine tumor necrosis factor-α (TNF-α) is produced by adipocytes, and its blood concentration is elevated in obese patients and declines with weight loss. Studies have demonstrated that TNF-α suppresses insulin action via its specific receptor; hence, it exacerbates insulin resistance. In addition to adipocytes, monocytes/macrophages produce large quantities of TNF-α. Thus, TNF-α, produced from monocytic cells due to inflammatory diseases, may have an additive influence on insulin sensitivity to adipocyte-derived TNF-α. Here, we hypothesized that 1) TNF-α produced by the adipose tissues of obese patients acts as a risk factor for periodontal inflammation, and 2) TNF-α produced due to periodontal inflammation may be an additional important factor influencing insulin sensitivity in both obese and type 2 diabetic patients. We believe that this interaction is a possible mechanism accounting for a 2-way relationship between type 2 diabetes and periodontal disease.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalJournal of Periodontology
Volume74
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

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Periodontal Diseases
Diabetes Mellitus
Tumor Necrosis Factor-alpha
Adipocytes
Insulin Resistance
Type 2 Diabetes Mellitus
Adipose Tissue
Obesity
Inflammation
Adipokines
Leptin
Hyperlipidemias
Energy Metabolism
Weight Loss
Monocytes
Macrophages
Body Weight
Insulin
Cytokines
Hypertension

Keywords

  • Diabetes mellitus, type 2
  • Insulin resistance
  • Obesity
  • Periodontal diseases/etiology
  • Risk factors
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Periodontal disease and diabetes mellitus : The role of tumor necrosis factor-α in a 2-way relationship. / Nishimura, Fusanori; Iwamoto, Yoshihiro; Mineshiba, Junji; Shimizu, Akemi; Soga, Yoshihiko; Murayama, Yoji.

In: Journal of Periodontology, Vol. 74, No. 1, 01.01.2003, p. 97-102.

Research output: Contribution to journalArticle

Nishimura, Fusanori ; Iwamoto, Yoshihiro ; Mineshiba, Junji ; Shimizu, Akemi ; Soga, Yoshihiko ; Murayama, Yoji. / Periodontal disease and diabetes mellitus : The role of tumor necrosis factor-α in a 2-way relationship. In: Journal of Periodontology. 2003 ; Vol. 74, No. 1. pp. 97-102.
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