Perineuronal nets of proteoglycans in the adult mouse brain are digested by collagenase

Takuro Murakami, Tetsuro Murakami, W. D. Su, Aiji Ohtsuka, Koji Abe, Yoshifumi Ninomiya

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

As our previous study has indicated, perineuronal proteoglycans in the adult mouse brain are associated with some collagenous molecules which can be stained with Gomori's ammoniacal silver and are resistant to hyaluronidase digestion. The present study demonstrated that these molecules are thoroughly digested with collagenase, and suggests that they represent a hyaluronic acid-binding domain of the ligand proteoglycans connecting the perineuronal proteoglycans and nerve cell surface glycoproteins.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
Journalarchives of histology and cytology
Volume62
Issue number2
DOIs
Publication statusPublished - May 1999

ASJC Scopus subject areas

  • Histology

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