Pericyte-coverage of human tumor vasculature and nanoparticle permeability

Liuzhe Zhang, Hiroshi Nishihara, Mitsunobu R. Kano

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Nano drug delivery systems (nanoDDS) are a promising strategy for treatment of human tumors. As indicated by our previous work, the extent of pericyte-coverage of tumor vasculature is important to determining nanoDDS efficacy since intratumoral accumulation of nanoDDS is less in tumor models with pericyte- covered vasculature. Here we investigated the clinical relevance of our previous observations in animal models, by determining pericyte coverage using immunohistochemistry of smooth muscle actin (SMA) with CD34: a vascular endothelial marker, in human tumor tissue samples. The investigation revealed that tumor vasculature coverage by pericytes in pancreatic and diffuse-type gastric cancers was significantly greater than in ovarian, colon, and intestinal-type gastric cancers. The latter group of cancers is easier to treat clinically. These observations are consistent with our previous findings in animal models. On the basis of these findings we believe optimization of nanoDDS delivery should be done depend upon a clear understanding of the effects of pericyte vascular coverage.

Original languageEnglish
Pages (from-to)761-766
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume35
Issue number5
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Keywords

  • Desmoplasia
  • Nano drug delivery system
  • Pericyte
  • Refractory tumor
  • Tumor vasculature

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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