Abstract
One of the problems in antigen-specific cancer immunotherapy is the low density of the tumor antigen-derived peptide endogenously presented on tumor cell surface major histocompatibility complex class I molecules. To overcome this, we are engaged in research on peptide intra-tumor injection to enhance tumor cell antigenicity. In in vivo studies using immunodeficient mice, the peptide injected into a solid mass of subcutaneous tumor was revealed to be loaded onto human leukocyte antigen class I molecules of tumor cells. In a peptide vaccine model and an adoptive cell transfer model using C57BL/6 mice, peptide intra-tumor injection was effective in terms of tumor growth inhibition and prolongation of survival time. Moreover, an antigen-spreading effect was detected after peptide intra-tumor injection. Peptide intra-tumor injection is an effective method of enhancing tumor cell antigenicity. It can induce additional peptide loading onto tumor cells, making tumor cells more antigenic for specific cytotoxic T-lymphocyte activity. Peptide intra-tumor injection may be a useful option for improvement of antigen-specific immunotherapy against solid tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 1234-1236 |
| Number of pages | 3 |
| Journal | Human Vaccines and Immunotherapeutics |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2013 |
Fingerprint
Keywords
- Antigen-derived peptide
- Cancer immunotherapy
- Cytotoxic T lymphocyte
- Major histocompatibility complex class I
- Tumor antigen
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology
Cite this
Peptide intra-tumor injection for cancer immunotherapy : Enhancement of tumor cell antigenicity is a novel and attractive strategy. / Nobuoka, Daisuke; Yoshikawa, Toshiaki; Fujiwara, Toshiyoshi; Nakatsura, Tetsuya.
In: Human Vaccines and Immunotherapeutics, Vol. 9, No. 6, 06.2013, p. 1234-1236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peptide intra-tumor injection for cancer immunotherapy
T2 - Enhancement of tumor cell antigenicity is a novel and attractive strategy
AU - Nobuoka, Daisuke
AU - Yoshikawa, Toshiaki
AU - Fujiwara, Toshiyoshi
AU - Nakatsura, Tetsuya
PY - 2013/6
Y1 - 2013/6
N2 - One of the problems in antigen-specific cancer immunotherapy is the low density of the tumor antigen-derived peptide endogenously presented on tumor cell surface major histocompatibility complex class I molecules. To overcome this, we are engaged in research on peptide intra-tumor injection to enhance tumor cell antigenicity. In in vivo studies using immunodeficient mice, the peptide injected into a solid mass of subcutaneous tumor was revealed to be loaded onto human leukocyte antigen class I molecules of tumor cells. In a peptide vaccine model and an adoptive cell transfer model using C57BL/6 mice, peptide intra-tumor injection was effective in terms of tumor growth inhibition and prolongation of survival time. Moreover, an antigen-spreading effect was detected after peptide intra-tumor injection. Peptide intra-tumor injection is an effective method of enhancing tumor cell antigenicity. It can induce additional peptide loading onto tumor cells, making tumor cells more antigenic for specific cytotoxic T-lymphocyte activity. Peptide intra-tumor injection may be a useful option for improvement of antigen-specific immunotherapy against solid tumors.
AB - One of the problems in antigen-specific cancer immunotherapy is the low density of the tumor antigen-derived peptide endogenously presented on tumor cell surface major histocompatibility complex class I molecules. To overcome this, we are engaged in research on peptide intra-tumor injection to enhance tumor cell antigenicity. In in vivo studies using immunodeficient mice, the peptide injected into a solid mass of subcutaneous tumor was revealed to be loaded onto human leukocyte antigen class I molecules of tumor cells. In a peptide vaccine model and an adoptive cell transfer model using C57BL/6 mice, peptide intra-tumor injection was effective in terms of tumor growth inhibition and prolongation of survival time. Moreover, an antigen-spreading effect was detected after peptide intra-tumor injection. Peptide intra-tumor injection is an effective method of enhancing tumor cell antigenicity. It can induce additional peptide loading onto tumor cells, making tumor cells more antigenic for specific cytotoxic T-lymphocyte activity. Peptide intra-tumor injection may be a useful option for improvement of antigen-specific immunotherapy against solid tumors.
KW - Antigen-derived peptide
KW - Cancer immunotherapy
KW - Cytotoxic T lymphocyte
KW - Major histocompatibility complex class I
KW - Tumor antigen
UR - http://www.scopus.com/inward/record.url?scp=84880682913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880682913&partnerID=8YFLogxK
U2 - 10.4161/hv.23990
DO - 10.4161/hv.23990
M3 - Article
VL - 9
SP - 1234
EP - 1236
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
SN - 2164-5515
IS - 6
ER -