Peptide 19 in the rat vagal and glossopharyngeal sensory ganglia

H. Ichikawa, T. Sugimoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peptide 19 (PEP 19) is a 7.6-kDa polypeptide which binds to calmodulin and inhibits calcium-calmodulin signaling. In this study, PEP 19-immunoreactivity (PEP 19-IR) was examined in the rat vagal and glossopharyngeal sensory ganglia. Twenty-nine percent, 59%, and 41% of sensory neurons contained PEP 19-IR in the jugular, petrosal, and nodose ganglia, respectively. These neurons were of various sizes (jugular, mean ± SD = 635.8 ± 392.6 μm 2, range = 105.9-1695.9 μm2; petrosal, mean ± SD = 370.9 ± 228.5 μm2, range = 57.7-1662.7 μm 2; nodose, mean ± SD = 380.5 ± 157 μm2, range = 87.5-950.4 μm2) and scattered throughout these ganglia. Double immunofluorescence method revealed that PEP 19-IR neurons which had parvalbumin-IR were rare in the ganglia (jugular, 4%; petrosal, 10%; nodose, 8%). PEP 19-IR neurons which contained calbindin D-28k were abundant in the petrosal (20%) and nodose (22%) ganglia but not in the jugular ganglion (8%). Retrograde tracing method indicated that many PEP 19-IR neurons projected to the circumvallate papilla and soft palate. In the soft palate, taste buds were innervated by PEP 19-IR nerve fibers. The present study suggests that PEP 19-IR neurons include chemoreceptors in the vagal and glossopharyngeal sensory ganglia.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalBrain Research
Volume1038
Issue number1
DOIs
Publication statusPublished - Mar 15 2005

Fingerprint

Sensory Ganglia
Peptides
Neurons
Neck
Nodose Ganglion
Ganglia
Soft Palate
Calmodulin
Taste Buds
rat peptide 19
Calbindins
Parvalbumins
Calcium Signaling
Sensory Receptor Cells
Nerve Fibers
Fluorescent Antibody Technique

Keywords

  • Calbindin D-28k
  • Jugular ganglion
  • Nodose ganglion
  • Parvalbumin
  • Peptide 19
  • Petrosal ganglion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Peptide 19 in the rat vagal and glossopharyngeal sensory ganglia. / Ichikawa, H.; Sugimoto, T.

In: Brain Research, Vol. 1038, No. 1, 15.03.2005, p. 107-112.

Research output: Contribution to journalArticle

Ichikawa, H. ; Sugimoto, T. / Peptide 19 in the rat vagal and glossopharyngeal sensory ganglia. In: Brain Research. 2005 ; Vol. 1038, No. 1. pp. 107-112.
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