Penicillin-cephalosporin conversion X. New synthesis of dithioazetidinones from thiazoline-azetidinones

Sigeru Torii, Hideo Tanaka, Takashi Siroi, Michio Sasaoka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

New ring-opening reaction of thiazoline-azetidinones 1 to dithioazetidinones 2 was achieved with 2-benzothiazolyl disulfide in aqueous acidic media and its potentiality for the preparation of a variety of cephalosporins 3 from various thiazoline-azetidinones 1 is demonstrated.

Original languageEnglish
Pages (from-to)2017-2020
Number of pages4
JournalTetrahedron Letters
Volume25
Issue number19
DOIs
Publication statusPublished - 1984

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Cephalosporins
Penicillins
Disulfides
2-azetidinone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Penicillin-cephalosporin conversion X. New synthesis of dithioazetidinones from thiazoline-azetidinones. / Torii, Sigeru; Tanaka, Hideo; Siroi, Takashi; Sasaoka, Michio.

In: Tetrahedron Letters, Vol. 25, No. 19, 1984, p. 2017-2020.

Research output: Contribution to journalArticle

Torii, Sigeru ; Tanaka, Hideo ; Siroi, Takashi ; Sasaoka, Michio. / Penicillin-cephalosporin conversion X. New synthesis of dithioazetidinones from thiazoline-azetidinones. In: Tetrahedron Letters. 1984 ; Vol. 25, No. 19. pp. 2017-2020.
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