Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ3-cephems

Sigeru Torii, Hideo Tanaka, Norio Saitoh, Takashi Siroi, Michio Sasaoka, Junzo Nokami

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achieved by the electrolytic ene-type chlorination of 1 in a CHC13-aqueous NaCl-H2SO4-(Pt electrodes) system and subsequent ring closure with NH3 in DMF.

Original languageEnglish
Pages (from-to)2187-2188
Number of pages2
JournalTetrahedron Letters
Volume23
Issue number21
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Torii, S., Tanaka, H., Saitoh, N., Siroi, T., Sasaoka, M., & Nokami, J. (1982). Penicillin-cephalosporin conversion III. A Novel route to 3-chloromethyl-Δ3-cephems. Tetrahedron Letters, 23(21), 2187-2188. https://doi.org/10.1016/S0040-4039(00)87295-0