Pemphigus antibodies mediate the development of an inflammatory change in the epidermis. A possible mechanism underlying the feature of eosinophilic spongiosis

K. Iwatsuki, H. Tagami, M. Yamada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The interaction between complement-fixing pemphigus antibodies and leukocytes was investigated by the in vitro leukocyte attachment test. Attachment of eosinophils as well as netrophils was induced by pemphigus antibodies at the intercellular space of epidermis in the presence of complement. This phenomenon was found to be produced by 7 out of 10 pemphigus sera in the indirect method using non-lesional skin as a substrate, and in 2 out of 7 biopsy specimens taken from perilesional skin without addition of any sera by the direct method. Those leukocytes bound specifically to the epidermis showed an enhanced function, i.e., vigorous incorporation of nitroblue tetrazolium dye complexes and formation of formazan crystals in the cytoplasms. The results of the present studies suggest that complement-fixing pemphigus antibodies mediate the development of an inflammatory change by inducing an infiltration of polymorphs in the epidermis, which is noted as eosinophilic spongiosis histologically.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalActa Dermato-Venereologica
Volume63
Issue number6
Publication statusPublished - 1983
Externally publishedYes

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Pemphigus
Epidermis
Leukocytes
Antibodies
Formazans
Nitroblue Tetrazolium
Skin
Extracellular Space
Serum
Eosinophils
Cytoplasm
Coloring Agents
Biopsy

ASJC Scopus subject areas

  • Dermatology

Cite this

Pemphigus antibodies mediate the development of an inflammatory change in the epidermis. A possible mechanism underlying the feature of eosinophilic spongiosis. / Iwatsuki, K.; Tagami, H.; Yamada, M.

In: Acta Dermato-Venereologica, Vol. 63, No. 6, 1983, p. 495-500.

Research output: Contribution to journalArticle

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