Pelvic lymphocyst infection associated with maternally inherited diabetes mellitus

Daisuke Ogawa, Kenichi Shikata, Mitsuhiro Matsuda, Jun Wada, Haruhito Adam Uchida, Maki Asada, Hirofumi Makino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 45-year-old woman with 20-year history of diabetes mellitus was admitted to our hospital because of high fever and abdominal pain. Radical hysterectomy and bilateral pelvic lymphadenectomy had been performed 4 months before admission for invasive cervical cancer. On admission, elastic hard tumors were palpable in the lower abdomen. Laboratory examination showed positive C-reactive protein (CRP), anemia and renal dysfunction. Computed tomography (CT) revealed several lymphocysts in the pelvis. She was diagnosed with infection of pelvic lymphocysts. Since her mother also had diabetes associated with deafness, we examined mitochondrial DNA in leukocytes and detected an A to G transition at the nucleotide position of 3243 (A3243G mutation). She was diagnosed as maternally inherited diabetes mellitus and deafness (MIDD). Puncture of the cysts followed by administration of antibiotics resulted in marked improvement of symptoms and laboratory findings. This is a rare case of pelvic lymphocyst infection in a patient with a mitochondrial disorder. Although the exact mechanism of infection is not clear, MIDD may represent an unusual risk factor for infection, and further investigation is necessary to assess the influence of mitochondrial dysfunction on the immune system. Pelvic lymphocyst infection should be considered in the differential diagnosis of abdominal pain and fever in patients with MIDD after abdominal surgery.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume61
Issue number2
DOIs
Publication statusPublished - Aug 1 2003

Fingerprint

Pelvic Infection
Diabetes Mellitus
Abdominal Pain
Fever
Mitochondrial Diseases
Deafness
Infection
Lymph Node Excision
Hysterectomy
Pelvis
Mitochondrial DNA
Punctures
Uterine Cervical Neoplasms
Abdomen
C-Reactive Protein
Cysts
Anemia
Immune System
Leukocytes
Differential Diagnosis

Keywords

  • A3243G mutation
  • Cervical cancer
  • Infection
  • Mitochondrial DNA
  • Pelvic lymphocysts

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Pelvic lymphocyst infection associated with maternally inherited diabetes mellitus. / Ogawa, Daisuke; Shikata, Kenichi; Matsuda, Mitsuhiro; Wada, Jun; Uchida, Haruhito Adam; Asada, Maki; Makino, Hirofumi.

In: Diabetes Research and Clinical Practice, Vol. 61, No. 2, 01.08.2003, p. 137-141.

Research output: Contribution to journalArticle

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