Abstract
Poly(ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles were prepared through the oil-in-water (O/W, ethyl acetate/water) emulsion technique using oil-soluble PEG-PLA in the presence of water-soluble PEG-PLA as a surfactant. The particle diameter decreased with increasing water-soluble PEG-PLA concentration, the smallest averaged diameter was 75 nm. From these results, it was found that water-soluble PEG-PLA acted as a surfactant which prevents further coalescence of droplets. In addition, the particles diameter decreased with increasing hydrophile-lipophile balance of oil-soluble PEG-PLA in the absence of water-soluble PEG-PLA. In contrast, the particle diameter was constant in the presence of water-soluble PEG-PLA. Therefore, the capability of water-soluble PEG-PLA as a surfactant was more excellent than that of oil-soluble PEG-PLA.
| Original language | English |
|---|---|
| Pages (from-to) | 969-971 |
| Number of pages | 3 |
| Journal | Materials Letters |
| Volume | 64 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 30 2010 |
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Keywords
- Colloidal carrier
- Emulsion solvent diffusion
- Nanomaterials
- Polymers
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
- Mechanical Engineering
- Mechanics of Materials
Cite this
PEG-PLA nanoparticles prepared by emulsion solvent diffusion using oil-soluble and water-soluble PEG-PLA. / Muranaka, Makoto; Hirota, Ken; Ono, Tsutomu.
In: Materials Letters, Vol. 64, No. 8, 30.04.2010, p. 969-971.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PEG-PLA nanoparticles prepared by emulsion solvent diffusion using oil-soluble and water-soluble PEG-PLA
AU - Muranaka, Makoto
AU - Hirota, Ken
AU - Ono, Tsutomu
PY - 2010/4/30
Y1 - 2010/4/30
N2 - Poly(ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles were prepared through the oil-in-water (O/W, ethyl acetate/water) emulsion technique using oil-soluble PEG-PLA in the presence of water-soluble PEG-PLA as a surfactant. The particle diameter decreased with increasing water-soluble PEG-PLA concentration, the smallest averaged diameter was 75 nm. From these results, it was found that water-soluble PEG-PLA acted as a surfactant which prevents further coalescence of droplets. In addition, the particles diameter decreased with increasing hydrophile-lipophile balance of oil-soluble PEG-PLA in the absence of water-soluble PEG-PLA. In contrast, the particle diameter was constant in the presence of water-soluble PEG-PLA. Therefore, the capability of water-soluble PEG-PLA as a surfactant was more excellent than that of oil-soluble PEG-PLA.
AB - Poly(ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles were prepared through the oil-in-water (O/W, ethyl acetate/water) emulsion technique using oil-soluble PEG-PLA in the presence of water-soluble PEG-PLA as a surfactant. The particle diameter decreased with increasing water-soluble PEG-PLA concentration, the smallest averaged diameter was 75 nm. From these results, it was found that water-soluble PEG-PLA acted as a surfactant which prevents further coalescence of droplets. In addition, the particles diameter decreased with increasing hydrophile-lipophile balance of oil-soluble PEG-PLA in the absence of water-soluble PEG-PLA. In contrast, the particle diameter was constant in the presence of water-soluble PEG-PLA. Therefore, the capability of water-soluble PEG-PLA as a surfactant was more excellent than that of oil-soluble PEG-PLA.
KW - Colloidal carrier
KW - Emulsion solvent diffusion
KW - Nanomaterials
KW - Polymers
UR - http://www.scopus.com/inward/record.url?scp=77249117126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77249117126&partnerID=8YFLogxK
U2 - 10.1016/j.matlet.2010.01.076
DO - 10.1016/j.matlet.2010.01.076
M3 - Article
AN - SCOPUS:77249117126
VL - 64
SP - 969
EP - 971
JO - Materials Letters
JF - Materials Letters
SN - 0167-577X
IS - 8
ER -