PEG-PLA nanoparticles prepared by emulsion solvent diffusion using oil-soluble and water-soluble PEG-PLA

Makoto Muranaka, Ken Hirota, Tsutomu Ono

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Poly(ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles were prepared through the oil-in-water (O/W, ethyl acetate/water) emulsion technique using oil-soluble PEG-PLA in the presence of water-soluble PEG-PLA as a surfactant. The particle diameter decreased with increasing water-soluble PEG-PLA concentration, the smallest averaged diameter was 75 nm. From these results, it was found that water-soluble PEG-PLA acted as a surfactant which prevents further coalescence of droplets. In addition, the particles diameter decreased with increasing hydrophile-lipophile balance of oil-soluble PEG-PLA in the absence of water-soluble PEG-PLA. In contrast, the particle diameter was constant in the presence of water-soluble PEG-PLA. Therefore, the capability of water-soluble PEG-PLA as a surfactant was more excellent than that of oil-soluble PEG-PLA.

Original languageEnglish
Pages (from-to)969-971
Number of pages3
JournalMaterials Letters
Volume64
Issue number8
DOIs
Publication statusPublished - Apr 30 2010

Keywords

  • Colloidal carrier
  • Emulsion solvent diffusion
  • Nanomaterials
  • Polymers

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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