Pedigree analysis of factor XI deficiency in Japanese black cattle

Yasunori Ohba, Masaki Takasu, Naohito Nishii, Eri Takeda, Sadatoshi Maeda, Tetsuo Kunieda, Hitoshi Kitagawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cattle with the factor XI deficiency. Results showed that the mutated allele of factor XI deficiency was retroactive in at least 6 or more generations of sires. Frequencies of the mutant gene were higher at 26.4% in total, and at 33.3% in sires. All 7 cattle with the homozygote of mutated allele were clinically normal, and showed no bleeding episodes. The mutated allele of factor XI deficiency might be widespread among Japanese black cattle.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalJournal of Veterinary Medical Science
Volume70
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Factor XI Deficiency
Wagyu
Pedigree
pedigree
sires
cattle
Alleles
alleles
Gene Frequency
Homozygote
homozygosity
dams (mothers)
Routine Diagnostic Tests
diagnostic techniques
gene frequency
hemorrhage
factor analysis
Japanese Black cattle
Factors
Hemorrhage

Keywords

  • Factor XI deficiency
  • Gene frequency
  • Japanese black cattle

ASJC Scopus subject areas

  • veterinary(all)
  • Marketing

Cite this

Pedigree analysis of factor XI deficiency in Japanese black cattle. / Ohba, Yasunori; Takasu, Masaki; Nishii, Naohito; Takeda, Eri; Maeda, Sadatoshi; Kunieda, Tetsuo; Kitagawa, Hitoshi.

In: Journal of Veterinary Medical Science, Vol. 70, No. 3, 03.2008, p. 297-299.

Research output: Contribution to journalArticle

Ohba, Y, Takasu, M, Nishii, N, Takeda, E, Maeda, S, Kunieda, T & Kitagawa, H 2008, 'Pedigree analysis of factor XI deficiency in Japanese black cattle', Journal of Veterinary Medical Science, vol. 70, no. 3, pp. 297-299. https://doi.org/10.1292/jvms.70.297
Ohba, Yasunori ; Takasu, Masaki ; Nishii, Naohito ; Takeda, Eri ; Maeda, Sadatoshi ; Kunieda, Tetsuo ; Kitagawa, Hitoshi. / Pedigree analysis of factor XI deficiency in Japanese black cattle. In: Journal of Veterinary Medical Science. 2008 ; Vol. 70, No. 3. pp. 297-299.
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