Pediatric intestinal Behçet disease complicated by myeloid malignancies

Kiichiro Kanamitsu; Akira Shimada; Ritsuo Nishiuchi; Tomonari Shigemura; Yozo Nakazawa; Kenichi Koike; Yuichi Kodama; Yuichi Shinkoda; Yoshifumi Kawano; Kozo Yasui; Koji Sasaki; Ryosuke Kajiwara; Hirokazu Tsukahara; Atsushi Manabe

doi:10.1007/s12185-016-2127-7

Pediatric intestinal Behçet disease complicated by myeloid malignancies

Kiichiro Kanamitsu, Akira Shimada, Ritsuo Nishiuchi, Tomonari Shigemura, Yozo Nakazawa, Kenichi Koike, Yuichi Kodama, Yuichi Shinkoda, Yoshifumi Kawano, Kozo Yasui, Koji Sasaki, Ryosuke Kajiwara, Hirokazu Tsukahara, Atsushi Manabe

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Behçet disease (BD) is rarely seen in children. Its clinical manifestations are believed to differ between pediatric and adult patients. The characteristics of BD complicated by myelodysplastic syndrome (MDS) are well established for adult patients; however, because only a few cases of pediatric-onset BD complicated by MDS have been reported, its clinical characteristics remain unknown. We here retrospectively review pediatric-onset BD complicated by myeloid malignancies in Japan, having identified five such patients. All patients were female and had gastrointestinal involvements, but lacked both major features of BD, i.e., uveitis and association with HLA-B51. All patients had advanced MDS or acute myeloid leukemia and received chemotherapy followed by hematopoietic stem cell transplantation. These five cases suggest that intestinal BD and myeloid malignancies have one or more pathophysiological mechanisms in common.

Original language	English
Pages (from-to)	377-382
Number of pages	6
Journal	International journal of hematology
Volume	105
Issue number	3
DOIs	https://doi.org/10.1007/s12185-016-2127-7
Publication status	Published - Mar 1 2017

Keywords

Gastrointestinal involvements
Myeloid malignancies
Pediatric-onset Behçet disease

ASJC Scopus subject areas

Hematology

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Pediatric intestinal Behçet disease complicated by myeloid malignancies. / Kanamitsu, Kiichiro ; Shimada, Akira; Nishiuchi, Ritsuo; Shigemura, Tomonari; Nakazawa, Yozo; Koike, Kenichi; Kodama, Yuichi; Shinkoda, Yuichi; Kawano, Yoshifumi; Yasui, Kozo; Sasaki, Koji; Kajiwara, Ryosuke; Tsukahara, Hirokazu; Manabe, Atsushi.

In: International journal of hematology, Vol. 105, No. 3, 01.03.2017, p. 377-382.

Research output: Contribution to journal › Article › peer-review

Kanamitsu, Kiichiro ; Shimada, Akira ; Nishiuchi, Ritsuo ; Shigemura, Tomonari ; Nakazawa, Yozo ; Koike, Kenichi ; Kodama, Yuichi ; Shinkoda, Yuichi ; Kawano, Yoshifumi ; Yasui, Kozo ; Sasaki, Koji ; Kajiwara, Ryosuke ; Tsukahara, Hirokazu ; Manabe, Atsushi. / Pediatric intestinal Behçet disease complicated by myeloid malignancies. In: International journal of hematology. 2017 ; Vol. 105, No. 3. pp. 377-382.

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abstract = "Beh{\c c}et disease (BD) is rarely seen in children. Its clinical manifestations are believed to differ between pediatric and adult patients. The characteristics of BD complicated by myelodysplastic syndrome (MDS) are well established for adult patients; however, because only a few cases of pediatric-onset BD complicated by MDS have been reported, its clinical characteristics remain unknown. We here retrospectively review pediatric-onset BD complicated by myeloid malignancies in Japan, having identified five such patients. All patients were female and had gastrointestinal involvements, but lacked both major features of BD, i.e., uveitis and association with HLA-B51. All patients had advanced MDS or acute myeloid leukemia and received chemotherapy followed by hematopoietic stem cell transplantation. These five cases suggest that intestinal BD and myeloid malignancies have one or more pathophysiological mechanisms in common.",

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AU - Koike, Kenichi

AU - Kodama, Yuichi

AU - Shinkoda, Yuichi

AU - Kawano, Yoshifumi

AU - Yasui, Kozo

AU - Sasaki, Koji

AU - Kajiwara, Ryosuke

AU - Tsukahara, Hirokazu

AU - Manabe, Atsushi

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