Pecan nut color: 90-days dietary toxicity study in F344 rats

Kiyoshi Sekita, Minoru Saito, Osayuki Uchida, Atsushi Ono, Yukio Ogawa, Toyozo Kaneko, Tsuyoshi Furuya, Yuji Kurokawa, Tohru Inoue

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A subchronic toxicity study of pecan nut color was performed using F344 rats of both genders. Pecan nut color, a flavonoid extracted from the coat of pecan nuts (Carya pecan ENGL. et GRAEBN.), is permitted for use as a food color by the Ministry of Health and Walfare, Japan. The product containing 60% dextrin (added in the process of manufacture) was used in the experiment. Rats were administered pecan nut color at concentrations of 0% (basal diet, control group), 0.5%, 3.0% and 5.0% in the basal powder diet for 90 days. Rats in the vehicle control group were given dextrin at the concentration of 3.0% in the same manner as used for the experimental groups. No significant changes related to pecan nut color or dextrin were found in body weight or food consumption throughout the observation period, or in hematology, serum chemistry or organ weights at autopsy. Furthermore, neither gross nor histological examination revealed any adverse effect or significant difference from the control. It is concluded that feeding of diet containing pecan nut color at a concentration of 5.0% (1,287 mg/kg/day for males and 1,344 mg/kg/day for females as mean intake of pecan nut color without dextrin) for 90 days has no adverse effect in rats.

Original languageEnglish
Pages (from-to)375-382
Number of pages8
JournalJournal of the Food Hygienic Society of Japan
Volume39
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • 90-days toxicity study
  • F344 rat
  • Flavonoid
  • Pecan nut color

ASJC Scopus subject areas

  • Food Science
  • Public Health, Environmental and Occupational Health

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