Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles

Takahiko Murata, Masahito Murai, Yuji Ikeda, Koji Miki, Kouichi Ohe

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A novel palladium- and copper-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles via Sonogashira coupling and double cyclization cascade involving imine formation has been developed. This reaction cascade proceeded under mild conditions, providing a powerful synthetic tool for the assembly of π-conjugated systems with a combination of palladium-catalyzed post-direct C-H bond arylations.

Original languageEnglish
Pages (from-to)2296-2299
Number of pages4
JournalOrganic Letters
Volume14
Issue number9
DOIs
Publication statusPublished - May 4 2012
Externally publishedYes

Fingerprint

Palladium
Dimers
palladium
cascades
dimers
Imines
Cyclization
synthesis
imines
Copper
assembly
copper

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles. / Murata, Takahiko; Murai, Masahito; Ikeda, Yuji; Miki, Koji; Ohe, Kouichi.

In: Organic Letters, Vol. 14, No. 9, 04.05.2012, p. 2296-2299.

Research output: Contribution to journalArticle

Murata, Takahiko ; Murai, Masahito ; Ikeda, Yuji ; Miki, Koji ; Ohe, Kouichi. / Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles. In: Organic Letters. 2012 ; Vol. 14, No. 9. pp. 2296-2299.
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