Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles

Takahiko Murata; Masahito Murai; Yuji Ikeda; Koji Miki; Kouichi Ohe

doi:10.1021/ol300718x

Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles

Takahiko Murata, Masahito Murai, Yuji Ikeda, Koji Miki, Kouichi Ohe

Graduate School of Natural Science and Technology

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A novel palladium- and copper-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles via Sonogashira coupling and double cyclization cascade involving imine formation has been developed. This reaction cascade proceeded under mild conditions, providing a powerful synthetic tool for the assembly of π-conjugated systems with a combination of palladium-catalyzed post-direct C-H bond arylations.

Original language	English
Pages (from-to)	2296-2299
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	9
DOIs	https://doi.org/10.1021/ol300718x
Publication status	Published - May 4 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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AU - Miki, Koji

AU - Ohe, Kouichi

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Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α′-dimers of heterocycles

Abstract

ASJC Scopus subject areas

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