PBSC collection from family donors in Japan: A prospective survey

Y. Kodera, K. Yamamoto, M. Harada, Y. Morishima, H. Dohy, S. Asano, Y. Ikeda, T. Nakahata, M. Imamura, K. Kawa, S. Kato, M. Tanimoto, Y. Kanda, R. Tanosaki, S. Shiobara, S. W. Kim, K. Nagafuji, M. Hino, K. Miyamura, R. SuzukiN. Hamajima, M. Fukushima, A. Tamakoshi, J. Halter, N. Schmitz, D. Niederwieser, A. Gratwohl

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Severe adverse events (SAE) and late hematological malignancies have been reported after PBSC donation. No prospective data on incidence and risk factors have been available for family donors so far. The Japan Society for Hematopoietic Cell Transplantation (JSHCT) introduced therefore in 2000 a mandatory registration system. It defined standards for donor eligibility and asked harvest centers to report any SAE immediately. All donors were examined at day 30 and were to be contacted once each year for a period of 5 years. Acute SAEs within day 30 were reported from 47/3264 donations (1.44%) with 14 events considered as unexpected and severe (0.58%). No donor died within 30 days. Late SAEs were reported from 39/1708 donors (2.3%). The incidence of acute SAEs was significantly higher among donors not matching the JSHCT standards (P=0.0023). Late hematological malignancies in PBSC donors were not different compared with a retrospective cohort of BM donors (N:1/1708 vs N:2/5921; P=0.53). In conclusion, acute and late SAEs do occur in PBSC donors at relatively low frequency but risk factors can be defined.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalBone Marrow Transplantation
Volume49
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Acute adverse events
  • Family donors
  • Late health problems
  • PBSC harvest (PBSCH)
  • Predictive factors
  • Prospective study

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Kodera, Y., Yamamoto, K., Harada, M., Morishima, Y., Dohy, H., Asano, S., Ikeda, Y., Nakahata, T., Imamura, M., Kawa, K., Kato, S., Tanimoto, M., Kanda, Y., Tanosaki, R., Shiobara, S., Kim, S. W., Nagafuji, K., Hino, M., Miyamura, K., ... Gratwohl, A. (2014). PBSC collection from family donors in Japan: A prospective survey. Bone Marrow Transplantation, 49(2), 195-200. https://doi.org/10.1038/bmt.2013.147