Patient Sensitivity to Polyethylene Particles with Cemented Total Hip Arthroplasty

Kentaro Ise, Keiichi Kawanabe, Takashi Matsusaki, Motoyuki Shimizu, Eijiro Onishi, Takashi Nakamura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To determine whether sensitivity to polyethylene particles varies among patients, we studied 25 patients who had undergone total hip arthroplasty. We used pelvic radiographs to measure annual polyethylene wear and the area of osteolysis. The ratio of the area of osteolysis to the volumetric polyethylene wear was defined as sensitivity index. Adherent cells from peripheral blood were cocultured with polyethylene particles, and the amount of bone-resorptive cytokines was measured. The amount of interleukin-6, but not of interleukin -1β or tumor necrosis factor-α, released from adherent cells in the in vitro experiment correlated with the in vivo sensitivity indices. This technique appears capable of predicting the development of polyethylene-induced osteolysis, allowing surgeons to avoid using polyethylene as the bearing surface in patients at risk for osteolysis.

Original languageEnglish
Pages (from-to)966-973
Number of pages8
JournalJournal of Arthroplasty
Volume22
Issue number7
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Fingerprint

Polyethylene
Arthroplasty
Hip
Osteolysis
Interleukin-1
Interleukin-6
Blood Cells
Tumor Necrosis Factor-alpha
Cytokines
Bone and Bones

Keywords

  • interleukin-6
  • polyethylene-induced osteolysis
  • prevention
  • sensitivity index
  • total hip arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Patient Sensitivity to Polyethylene Particles with Cemented Total Hip Arthroplasty. / Ise, Kentaro; Kawanabe, Keiichi; Matsusaki, Takashi; Shimizu, Motoyuki; Onishi, Eijiro; Nakamura, Takashi.

In: Journal of Arthroplasty, Vol. 22, No. 7, 10.2007, p. 966-973.

Research output: Contribution to journalArticle

Ise, Kentaro ; Kawanabe, Keiichi ; Matsusaki, Takashi ; Shimizu, Motoyuki ; Onishi, Eijiro ; Nakamura, Takashi. / Patient Sensitivity to Polyethylene Particles with Cemented Total Hip Arthroplasty. In: Journal of Arthroplasty. 2007 ; Vol. 22, No. 7. pp. 966-973.
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