Abstract
Despite advances in the development of powerful antibiotics and intensive care unit, sepsis is still life threatening and the mortality rate remains unchanged for the past three decades. Recent prospective trials with biological response modifiers have shown a modest clinical benefit. The pathological basis of sepsis is initially an excessive inflammatory response against invading pathogens, leading to systemic inflammatory response syndrome (SIRS). Evidence reveals that a variety of inflammatory mediators orchestrate the intense inflammation through complicated cellular interactions. More recent data indicate that most septic patients survive this stage and then subjected to an immunoparalysis phase, termed compensatory anti-inflammatory response syndrome (CARS), which is more fatal than the initial phase. Sepsis is a complicated clinical syndrome with multiple physiologic and immunologic abnormalities. In this review, we summarize the recent understandings of the pathophysiology of sepsis, and introduce recent patents on diagnosis, treatment and prophylaxis for sepsis.
| Original language | English |
|---|---|
| Pages (from-to) | 26-32 |
| Number of pages | 7 |
| Journal | Recent Patents on Inflammation and Allergy Drug Discovery |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Anti-inflammatory response syndrome
- Multiple organ failure
- Sepsis
- Septic shock
- Systemic inflammatory response syndrome
ASJC Scopus subject areas
- Drug Discovery
- Immunology and Allergy
Cite this
Pathophysiology of sepsis and recent patents on the diagnosis, treatment and prophylaxis for sepsis. / Okazaki, Yasumasa; Matsukawa, Akihiro.
In: Recent Patents on Inflammation and Allergy Drug Discovery, Vol. 3, No. 1, 2009, p. 26-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathophysiology of sepsis and recent patents on the diagnosis, treatment and prophylaxis for sepsis
AU - Okazaki, Yasumasa
AU - Matsukawa, Akihiro
PY - 2009
Y1 - 2009
N2 - Despite advances in the development of powerful antibiotics and intensive care unit, sepsis is still life threatening and the mortality rate remains unchanged for the past three decades. Recent prospective trials with biological response modifiers have shown a modest clinical benefit. The pathological basis of sepsis is initially an excessive inflammatory response against invading pathogens, leading to systemic inflammatory response syndrome (SIRS). Evidence reveals that a variety of inflammatory mediators orchestrate the intense inflammation through complicated cellular interactions. More recent data indicate that most septic patients survive this stage and then subjected to an immunoparalysis phase, termed compensatory anti-inflammatory response syndrome (CARS), which is more fatal than the initial phase. Sepsis is a complicated clinical syndrome with multiple physiologic and immunologic abnormalities. In this review, we summarize the recent understandings of the pathophysiology of sepsis, and introduce recent patents on diagnosis, treatment and prophylaxis for sepsis.
AB - Despite advances in the development of powerful antibiotics and intensive care unit, sepsis is still life threatening and the mortality rate remains unchanged for the past three decades. Recent prospective trials with biological response modifiers have shown a modest clinical benefit. The pathological basis of sepsis is initially an excessive inflammatory response against invading pathogens, leading to systemic inflammatory response syndrome (SIRS). Evidence reveals that a variety of inflammatory mediators orchestrate the intense inflammation through complicated cellular interactions. More recent data indicate that most septic patients survive this stage and then subjected to an immunoparalysis phase, termed compensatory anti-inflammatory response syndrome (CARS), which is more fatal than the initial phase. Sepsis is a complicated clinical syndrome with multiple physiologic and immunologic abnormalities. In this review, we summarize the recent understandings of the pathophysiology of sepsis, and introduce recent patents on diagnosis, treatment and prophylaxis for sepsis.
KW - Anti-inflammatory response syndrome
KW - Multiple organ failure
KW - Sepsis
KW - Septic shock
KW - Systemic inflammatory response syndrome
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UR - http://www.scopus.com/inward/citedby.url?scp=61449149742&partnerID=8YFLogxK
U2 - 10.2174/187221309787158416
DO - 10.2174/187221309787158416
M3 - Article
C2 - 19149743
AN - SCOPUS:61449149742
VL - 3
SP - 26
EP - 32
JO - Recent Patents on Inflammation and Allergy Drug Discovery
JF - Recent Patents on Inflammation and Allergy Drug Discovery
SN - 1872-213X
IS - 1
ER -