Pathophysiological changes in the airways of asthma patients with aging.

Y. Tanizaki, H. Kitani, M. Okazaki, T. Mifune, Fumihiro Mitsunobu, N. Honke, I. Kimura

Research output: Contribution to journalArticle

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Abstract

Pathophysiological changes in the airways with aging were examined in 78 patients with bronchial asthma. The FEV1.0% values in patients over the age of 71, and the %MMF, %V50 and %V25 values in those over 51 were significantly lower than those of patients between the ages of 10 and 30. The frequency of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly higher in patients aged between 61 and 70 than in those aged between 41 and 50 (p <0.05). The frequency of each clinical asthma type changed with aging; the number of patients with simple bronchoconstriction type (type Ia) decreased with increasing age in patients under the age of 60, and the number of those with bronchiolar obstruction type (type II) increased with aging. The frequency of patients with bronchoconstriction+hypersecretion type (type Ib) showed a peak between the ages of 51 and 60. Bronchial reactivity to methacholine showed a tendency to decrease with aging. The release of histamine from leucocytes induced by Ca ionophore A23187 was significantly higher in patients between the ages of 10 and 30 than in those between the ages of 51 and 60 (p <0.05) and between 61 and 70 (p <0.01).

Original languageEnglish
Pages (from-to)1380-1387
Number of pages8
JournalArerugī = [Allergy]
Volume41
Issue number9
Publication statusPublished - Sep 1992

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Asthma
Bronchoconstriction
Methacholine Chloride
Histamine Release
Ionophores
Calcimycin
Bronchoalveolar Lavage Fluid
Leukocytes
Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Tanizaki, Y., Kitani, H., Okazaki, M., Mifune, T., Mitsunobu, F., Honke, N., & Kimura, I. (1992). Pathophysiological changes in the airways of asthma patients with aging. Arerugī = [Allergy], 41(9), 1380-1387.

Pathophysiological changes in the airways of asthma patients with aging. / Tanizaki, Y.; Kitani, H.; Okazaki, M.; Mifune, T.; Mitsunobu, Fumihiro; Honke, N.; Kimura, I.

In: Arerugī = [Allergy], Vol. 41, No. 9, 09.1992, p. 1380-1387.

Research output: Contribution to journalArticle

Tanizaki, Y, Kitani, H, Okazaki, M, Mifune, T, Mitsunobu, F, Honke, N & Kimura, I 1992, 'Pathophysiological changes in the airways of asthma patients with aging.', Arerugī = [Allergy], vol. 41, no. 9, pp. 1380-1387.
Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Honke N et al. Pathophysiological changes in the airways of asthma patients with aging. Arerugī = [Allergy]. 1992 Sep;41(9):1380-1387.
Tanizaki, Y. ; Kitani, H. ; Okazaki, M. ; Mifune, T. ; Mitsunobu, Fumihiro ; Honke, N. ; Kimura, I. / Pathophysiological changes in the airways of asthma patients with aging. In: Arerugī = [Allergy]. 1992 ; Vol. 41, No. 9. pp. 1380-1387.
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