Pathology of the temporomandibular joint of patients with rheumatoid arthritis - Case reports of secondary amyloidosis and macrophage populations

Takaaki Ueno, Toshimasa Kagawa, Miwa Kanou, Nobuhisa Ishida, Takashi Fujii, Joji Fukunaga, Nobuyoshi Mizukawa, Toshio Sugahara

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: The pathogenetic features of rheumatoid arthritis of the temporomandibular joint (TMJ) are not well defined. In this paper the histological features of TMJs affected by rheumatoid arthritis, and the detection of secondary amyloidosis and macrophage populations in the TMJs of two patients with progressive rheumatoid arthritis are described. Methods: In two patients (64-year-old man and 61-year-old woman) with rheumatoid arthritis total TMJ replacement were performed. The surgical specimens were studied histologically. Results: It was found that the articular cartilage had been completely replaced by proliferating fibrous tissue. Congo red staining and polarizing microscopy revealed amyloid deposition in the connective tissue of the joint space. Immunohistochemical staining showed CD 68 positive macrophages around the amyloid deposition in the proliferating soft tissue. Conclusion: TMJ involvement in rheumatoid arthritis followed the same destructive pathway as in other joints. Amyloid deposition and macrophage populations were detected in two TMJs affected by rheumatoid arthritis.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalJournal of Cranio-Maxillofacial Surgery
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 2003

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Temporomandibular Joint
Amyloidosis
Rheumatoid Arthritis
Macrophages
Pathology
Amyloid
Population
Replacement Arthroplasties
Joints
Staining and Labeling
Congo Red
Articular Cartilage
Connective Tissue
Microscopy

ASJC Scopus subject areas

  • Dentistry(all)
  • Otorhinolaryngology
  • Surgery

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Pathology of the temporomandibular joint of patients with rheumatoid arthritis - Case reports of secondary amyloidosis and macrophage populations. / Ueno, Takaaki; Kagawa, Toshimasa; Kanou, Miwa; Ishida, Nobuhisa; Fujii, Takashi; Fukunaga, Joji; Mizukawa, Nobuyoshi; Sugahara, Toshio.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 31, No. 4, 08.2003, p. 252-256.

Research output: Contribution to journalArticle

Ueno, Takaaki ; Kagawa, Toshimasa ; Kanou, Miwa ; Ishida, Nobuhisa ; Fujii, Takashi ; Fukunaga, Joji ; Mizukawa, Nobuyoshi ; Sugahara, Toshio. / Pathology of the temporomandibular joint of patients with rheumatoid arthritis - Case reports of secondary amyloidosis and macrophage populations. In: Journal of Cranio-Maxillofacial Surgery. 2003 ; Vol. 31, No. 4. pp. 252-256.
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