Abstract
Introduction: The pathogenetic features of rheumatoid arthritis of the temporomandibular joint (TMJ) are not well defined. In this paper the histological features of TMJs affected by rheumatoid arthritis, and the detection of secondary amyloidosis and macrophage populations in the TMJs of two patients with progressive rheumatoid arthritis are described. Methods: In two patients (64-year-old man and 61-year-old woman) with rheumatoid arthritis total TMJ replacement were performed. The surgical specimens were studied histologically. Results: It was found that the articular cartilage had been completely replaced by proliferating fibrous tissue. Congo red staining and polarizing microscopy revealed amyloid deposition in the connective tissue of the joint space. Immunohistochemical staining showed CD 68 positive macrophages around the amyloid deposition in the proliferating soft tissue. Conclusion: TMJ involvement in rheumatoid arthritis followed the same destructive pathway as in other joints. Amyloid deposition and macrophage populations were detected in two TMJs affected by rheumatoid arthritis.
| Original language | English |
|---|---|
| Pages (from-to) | 252-256 |
| Number of pages | 5 |
| Journal | Journal of Cranio-Maxillofacial Surgery |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2003 |
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ASJC Scopus subject areas
- Dentistry(all)
- Otorhinolaryngology
- Surgery
Cite this
Pathology of the temporomandibular joint of patients with rheumatoid arthritis - Case reports of secondary amyloidosis and macrophage populations. / Ueno, Takaaki; Kagawa, Toshimasa; Kanou, Miwa; Ishida, Nobuhisa; Fujii, Takashi; Fukunaga, Joji; Mizukawa, Nobuyoshi; Sugahara, Toshio.
In: Journal of Cranio-Maxillofacial Surgery, Vol. 31, No. 4, 08.2003, p. 252-256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pathology of the temporomandibular joint of patients with rheumatoid arthritis - Case reports of secondary amyloidosis and macrophage populations
AU - Ueno, Takaaki
AU - Kagawa, Toshimasa
AU - Kanou, Miwa
AU - Ishida, Nobuhisa
AU - Fujii, Takashi
AU - Fukunaga, Joji
AU - Mizukawa, Nobuyoshi
AU - Sugahara, Toshio
PY - 2003/8
Y1 - 2003/8
N2 - Introduction: The pathogenetic features of rheumatoid arthritis of the temporomandibular joint (TMJ) are not well defined. In this paper the histological features of TMJs affected by rheumatoid arthritis, and the detection of secondary amyloidosis and macrophage populations in the TMJs of two patients with progressive rheumatoid arthritis are described. Methods: In two patients (64-year-old man and 61-year-old woman) with rheumatoid arthritis total TMJ replacement were performed. The surgical specimens were studied histologically. Results: It was found that the articular cartilage had been completely replaced by proliferating fibrous tissue. Congo red staining and polarizing microscopy revealed amyloid deposition in the connective tissue of the joint space. Immunohistochemical staining showed CD 68 positive macrophages around the amyloid deposition in the proliferating soft tissue. Conclusion: TMJ involvement in rheumatoid arthritis followed the same destructive pathway as in other joints. Amyloid deposition and macrophage populations were detected in two TMJs affected by rheumatoid arthritis.
AB - Introduction: The pathogenetic features of rheumatoid arthritis of the temporomandibular joint (TMJ) are not well defined. In this paper the histological features of TMJs affected by rheumatoid arthritis, and the detection of secondary amyloidosis and macrophage populations in the TMJs of two patients with progressive rheumatoid arthritis are described. Methods: In two patients (64-year-old man and 61-year-old woman) with rheumatoid arthritis total TMJ replacement were performed. The surgical specimens were studied histologically. Results: It was found that the articular cartilage had been completely replaced by proliferating fibrous tissue. Congo red staining and polarizing microscopy revealed amyloid deposition in the connective tissue of the joint space. Immunohistochemical staining showed CD 68 positive macrophages around the amyloid deposition in the proliferating soft tissue. Conclusion: TMJ involvement in rheumatoid arthritis followed the same destructive pathway as in other joints. Amyloid deposition and macrophage populations were detected in two TMJs affected by rheumatoid arthritis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0042324316&partnerID=8YFLogxK
U2 - 10.1016/S1010-5182(03)00031-3
DO - 10.1016/S1010-5182(03)00031-3
M3 - Article
C2 - 12914711
AN - SCOPUS:0042324316
VL - 31
SP - 252
EP - 256
JO - Journal of Cranio-Maxillo-Facial Surgery
JF - Journal of Cranio-Maxillo-Facial Surgery
SN - 1010-5182
IS - 4
ER -