Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

Yuka Sogabe; Katsuya Miyatani; Rieko Goto; Gengo Ishii; Kohichi Ohshima; Yasuharu Sato

doi:10.1007/s10384-012-0170-3

Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

Yuka Sogabe, Katsuya Miyatani, Rieko Goto, Gengo Ishii, Kohichi Ohshima, Yasuharu Sato

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

Original language	English
Pages (from-to)	511-514
Number of pages	4
Journal	Japanese Journal of Ophthalmology
Volume	56
Issue number	5
DOIs	https://doi.org/10.1007/s10384-012-0170-3
Publication status	Published - Sept 2012

Keywords

IgG4-related disease
Infraorbital nerve
Nerve tumor
Orbital tumor
Trigeminal nerve lesion

ASJC Scopus subject areas

Ophthalmology

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10.1007/s10384-012-0170-3

Cite this

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title = "Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease",

abstract = "Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.",

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author = "Yuka Sogabe and Katsuya Miyatani and Rieko Goto and Gengo Ishii and Kohichi Ohshima and Yasuharu Sato",

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T1 - Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

AU - Sogabe, Yuka

AU - Miyatani, Katsuya

AU - Goto, Rieko

AU - Ishii, Gengo

AU - Ohshima, Kohichi

AU - Sato, Yasuharu

PY - 2012/9

Y1 - 2012/9

N2 - Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

AB - Purpose: We report a case of bilateral infraorbital nerve enlargement (IONE) associated with immunoglobulin (Ig)G4-related ophthalmic disease and describe the associated histopathologic findings. Case: An otherwise healthy 59-year-old man presented with bilateral exophthalmos and right visual disturbance. Orbital magnetic resonance imaging showed bilateral IONE and a soft tissue mass in the right orbit. Excisional biopsy in the left infraorbital canal was performed. Histopathologic assessment revealed igG4-related disease involving the epineurium of the infraorbital nerve. The patient received systemic steroid therapy, to which he responded well. Conclusion: IONE in igG4-related ophthalmic disease is due to igG4-related disease involving the epineurium.

KW - IgG4-related disease

KW - Infraorbital nerve

KW - Nerve tumor

KW - Orbital tumor

KW - Trigeminal nerve lesion

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Pathological findings of infraorbital nerve enlargement in igG4-related ophthalmic disease

Abstract

Keywords

ASJC Scopus subject areas

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