Pathological complete response in a case of advanced gastric cancer after neoadjuvant chemotherapy

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Abstract

A 62-year-old man with advanced gastric cancer was referred to our hospital. A gastroscopy revealed a type 3 tumor invading the esophagus in the lesser curvature of the stomach cardia. We diagnosed the tumor as cStage IIIB (T4BN1M0) gastric cancer. For the best chance of a pathological complete response, we selected neoadjuvant chemotherapy (NAC) with S-1 + CDDP (SP therapy). A total gastrectomy with lymph node dissection was performed after 2 courses of SP therapy-Pathological evaluation of the resected stomach and lymph nodes indicated an absence of cancerous cells, confirming a pathological complete response (pCR). The patient has been followed up for 4 months without evidence of recurrence.

Original languageEnglish
Pages (from-to)2282-2284
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume41
Issue number12
Publication statusPublished - Nov 1 2014

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Stomach Neoplasms
Stomach
Drug Therapy
Gastroscopy
Cardia
Gastrectomy
Lymph Node Excision
Esophagus
Neoplasms
Lymph Nodes
Recurrence
Therapeutics

Keywords

  • Gastric cancer
  • NAC
  • PCR

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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abstract = "A 62-year-old man with advanced gastric cancer was referred to our hospital. A gastroscopy revealed a type 3 tumor invading the esophagus in the lesser curvature of the stomach cardia. We diagnosed the tumor as cStage IIIB (T4BN1M0) gastric cancer. For the best chance of a pathological complete response, we selected neoadjuvant chemotherapy (NAC) with S-1 + CDDP (SP therapy). A total gastrectomy with lymph node dissection was performed after 2 courses of SP therapy-Pathological evaluation of the resected stomach and lymph nodes indicated an absence of cancerous cells, confirming a pathological complete response (pCR). The patient has been followed up for 4 months without evidence of recurrence.",
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author = "Satoru Kikuchi and Shunsuke Kagawa and Tetsushi Kubota and Kazuya Kuwada and Shinji Kuroda and Masahiko Nishizaki and Takehiro Tanaka and Toshiyoshi Fujiwara",
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AU - Kikuchi, Satoru

AU - Kagawa, Shunsuke

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AU - Kuwada, Kazuya

AU - Kuroda, Shinji

AU - Nishizaki, Masahiko

AU - Tanaka, Takehiro

AU - Fujiwara, Toshiyoshi

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N2 - A 62-year-old man with advanced gastric cancer was referred to our hospital. A gastroscopy revealed a type 3 tumor invading the esophagus in the lesser curvature of the stomach cardia. We diagnosed the tumor as cStage IIIB (T4BN1M0) gastric cancer. For the best chance of a pathological complete response, we selected neoadjuvant chemotherapy (NAC) with S-1 + CDDP (SP therapy). A total gastrectomy with lymph node dissection was performed after 2 courses of SP therapy-Pathological evaluation of the resected stomach and lymph nodes indicated an absence of cancerous cells, confirming a pathological complete response (pCR). The patient has been followed up for 4 months without evidence of recurrence.

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