Pathological change of articular cartilage in the mandibular head treated with immunosuppressant FK 506

Takaaki Ueno, T. Kagawa, M. Kanou, T. Fujii, J. Fukunaga, Nobuyoshi Mizukawa, T. Sugahara, T. Yamamoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

While several reports have documented immunosuppressant-induced osteoporosis, the exact mechanism of the pathological change of the joint remains to be clarified. In the present study, we have demonstrated the pathological change of the articular cartilage in the mandibular head of five Sprague-Dawley rats administered with the immunosuppressant FK 506 for 28 days. Three-dimensional micro-computed tomography of the mandibular heads in treated rats showed a significant decrease in trabecular bone volume compared to control rats. Histological observation revealed atrophic change of the articular cartilage. Immunohistological observation using anti-proliferative cell nuclear antibody (PCNA), type I, II, and type X collagen antibodies showed significantly decreased proliferation and differentiation of chondrocytes in the articular cartilage compared with the control group (p

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalHistology and Histopathology
Volume19
Issue number1
Publication statusPublished - Jan 2004

Fingerprint

Articular Cartilage
Tacrolimus
Immunosuppressive Agents
Head
Collagen Type X
Observation
Antibodies
Chondrocytes
Osteoporosis
Sprague Dawley Rats
Joints
Tomography
Control Groups

Keywords

  • Atrophy
  • Cartilage
  • Head
  • Immunosuppressant FK 506
  • Mandibular
  • Osteoporosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Ueno, T., Kagawa, T., Kanou, M., Fujii, T., Fukunaga, J., Mizukawa, N., ... Yamamoto, T. (2004). Pathological change of articular cartilage in the mandibular head treated with immunosuppressant FK 506. Histology and Histopathology, 19(1), 15-21.

Pathological change of articular cartilage in the mandibular head treated with immunosuppressant FK 506. / Ueno, Takaaki; Kagawa, T.; Kanou, M.; Fujii, T.; Fukunaga, J.; Mizukawa, Nobuyoshi; Sugahara, T.; Yamamoto, T.

In: Histology and Histopathology, Vol. 19, No. 1, 01.2004, p. 15-21.

Research output: Contribution to journalArticle

Ueno, T, Kagawa, T, Kanou, M, Fujii, T, Fukunaga, J, Mizukawa, N, Sugahara, T & Yamamoto, T 2004, 'Pathological change of articular cartilage in the mandibular head treated with immunosuppressant FK 506', Histology and Histopathology, vol. 19, no. 1, pp. 15-21.
Ueno, Takaaki ; Kagawa, T. ; Kanou, M. ; Fujii, T. ; Fukunaga, J. ; Mizukawa, Nobuyoshi ; Sugahara, T. ; Yamamoto, T. / Pathological change of articular cartilage in the mandibular head treated with immunosuppressant FK 506. In: Histology and Histopathology. 2004 ; Vol. 19, No. 1. pp. 15-21.
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